(R)-3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid

Base Information

Chemical Name:(R)-3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid
CAS No.:1390644-41-3
Molecular Formula:C₂₆H₃₃NO₄
Molecular Weight:423.552
Hs Code.:

Synonyms:(R)-3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid

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Chemical Property of (R)-3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid

Chemical Property:

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Technology Process of (R)-3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid

There total 21 articles about (R)-3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1390644-42-4
3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid

: 1390644-41-3
(R)-3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid

Guidance literature:: 3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid; With D-tartaric acid; In isopropyl alcohol; at 30 - 35 ℃; for 16h;

With water; sodium hydroxide; In dichloromethane; at 10 - 15 ℃;

Reference yield:

: 920-46-7,26937-45-1
Methacryloyl chloride

: 194482-44-5
Tolterodine acid

: 1390644-41-3
(R)-3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid

Guidance literature:: In chloroform; at -45 - -35 ℃; for 0.75h;

Reference yield:

: 106-41-2
4-bromo-phenol

: 1390644-41-3
(R)-3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: sulfuric acid / 12 h / 120 - 125 °C

2.1: potassium carbonate; sodium iodide / acetone / 25 - 30 °C

2.2: 5.5 h / 15 °C / Reflux

3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 4 h / 5 - 10 °C / Inert atmosphere

4.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 5 °C

5.1: acetonitrile / 32 h / 95 - 100 °C / autoclave; Inert atmosphere

6.1: n-butyllithium / tetrahydrofuran / 0.75 h / -65 - -55 °C

7.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C

7.2: 10 - 15 °C

8.1: hydrogen / 5%-palladium/activated carbon / methanol / 8 h / 25 - 30 °C / 2206.72 - 2942.29 Torr / autoclave

9.1: hydrogen / 5%-palladium/activated carbon / methanol / 8 h / 25 - 30 °C / 2206.72 - 2942.29 Torr / autoclave

10.1: chloroform / 0.75 h / -45 - -35 °C

11.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C

11.2: 10 - 15 °C

With dmap; n-butyllithium; D-tartaric acid; sulfuric acid; hydrogen; potassium carbonate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium iodide; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; dichloromethane; chloroform; isopropyl alcohol; acetone; toluene; acetonitrile;