(R)-N,N-diisopropyl-3-phenyl-3-(5-formyl-2-hydroxyphenyl)propyl-1-amine

Base Information

• Chemical Name: (R)-N,N-diisopropyl-3-phenyl-3-(5-formyl-2-hydroxyphenyl)propyl-1-amine
• CAS No.: 214601-12-4
• Molecular Formula: C₂₂H₂₉NO₂
• Molecular Weight: 339.478
• Mol file: 214601-12-4.mol

Synonyms:(R)-N,N-diisopropyl-3-phenyl-3-(5-formyl-2-hydroxyphenyl)propyl-1-amine

Chemical Property of (R)-N,N-diisopropyl-3-phenyl-3-(5-formyl-2-hydroxyphenyl)propyl-1-amine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxy-benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxy-benzaldehyde can be used in the synthesis of arylphenylpropanamines as anticholinergic agents.

Technology Process of (R)-N,N-diisopropyl-3-phenyl-3-(5-formyl-2-hydroxyphenyl)propyl-1-amine

There total 25 articles about (R)-N,N-diisopropyl-3-phenyl-3-(5-formyl-2-hydroxyphenyl)propyl-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + (E)-N,N-diisopropyl-3-phenylprop-2-en-1-amine (173948-30-6) → (R)-N,N-diisopropyl-3-phenyl-3-(5-formyl-2-hydroxyphenyl)propyl-1-amine (214601-12-4)

Guidance literature:

4-hydroxy-benzaldehyde; (E)-N,N-diisopropyl-3-phenylprop-2-en-1-amine; With methanesulfonic acid; at 130 ℃; for 8h;

In water; toluene; pH=9.5; Product distribution / selectivity;

Reference yield:

(R)-[4-benzyloxy-3-(3-diisopropylamino-1-phenyl-propyl)-phenyl]-methanal (214601-54-4) → (R)-N,N-diisopropyl-3-phenyl-3-(5-formyl-2-hydroxyphenyl)propyl-1-amine (214601-12-4)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol; at 25 - 30 ℃; for 8h; under 2206.72 - 2942.29 Torr; autoclave;

Reference yield:

(R)-(-)-3-(3-diisopropylamino-1-phenylpropyl)-4-hydroxybenzoic acid methyl ester (214601-16-8) → (R)-N,N-diisopropyl-3-phenyl-3-(5-formyl-2-hydroxyphenyl)propyl-1-amine (214601-12-4)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 1h; Inert atmosphere;

upstream raw materials:

(R)-N,N-diisopropyl-3-phenyl-3-(5-formyl-2-triisopropylsilyloxyphenyl)propyl-1-amine

N,N-dimethyl-formamide

4-hydroxy-benzaldehyde

(E)-N,N-diisopropyl-3-phenylprop-2-en-1-amine

Downstream raw materials:

(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol

racemic 3-(3-N,N'-diisopropylamino-1-phenyl-propyl)-4-hydroxy-benzoic acid

(R)-3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid

3-(3-(diisopropylamino)-1-phenylpropyl)-4-(methacryloyloxy)benzoic acid