((1S,2S,3S,4R,5S)-2-Chloromethyl-3-methyl-5-phenylsulfanyl-tricyclo[2.2.1.0^2,6]hept-3-yl)-acetonitrile

Base Information

• Chemical Name: ((1S,2S,3S,4R,5S)-2-Chloromethyl-3-methyl-5-phenylsulfanyl-tricyclo[2.2.1.0^2,6]hept-3-yl)-acetonitrile
• CAS No.: 78173-28-1
• Molecular Formula: C₁₇H₁₈ClNS
• Molecular Weight: 303.856

Synonyms:((1S,2S,3S,4R,5S)-2-Chloromethyl-3-methyl-5-phenylsulfanyl-tricyclo[2.2.1.0^2,6]hept-3-yl)-acetonitrile

Chemical Property of ((1S,2S,3S,4R,5S)-2-Chloromethyl-3-methyl-5-phenylsulfanyl-tricyclo[2.2.1.0^2,6]hept-3-yl)-acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1S,2S,3S,4R,5S)-2-Chloromethyl-3-methyl-5-phenylsulfanyl-tricyclo[2.2.1.0^2,6]hept-3-yl)-acetonitrile

There total 3 articles about ((1S,2S,3S,4R,5S)-2-Chloromethyl-3-methyl-5-phenylsulfanyl-tricyclo[2.2.1.0^2,6]hept-3-yl)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

((1R,2S,4S)-2-Methyl-3-methylene-bicyclo[2.2.1]hept-5-en-2-yl)-acetonitrile (77228-95-6,78173-27-0) + benzenesulfenyl chloride (931-59-9) → ((1S,2S,3S,4R,5S)-2-Chloromethyl-3-methyl-5-phenylsulfanyl-tricyclo[2.2.1.02,6]hept-3-yl)-acetonitrile (78173-28-1)

Guidance literature:

In dichloromethane; at 0 ℃;

DOI:10.1016/0040-4039(80)88099-3

Reference yield:

C24H28O6S2 (63025-84-3,78173-26-9) → ((1S,2S,3S,4R,5S)-2-Chloromethyl-3-methyl-5-phenylsulfanyl-tricyclo[2.2.1.02,6]hept-3-yl)-acetonitrile (78173-28-1)

Guidance literature:

Multi-step reaction with 3 steps

1: LiBr / hexamethylphosphoric acid triamide / 4 h / 120 °C

2: hexamethylphosphoric acid triamide / 12 h / 120 °C

3: 85 percent / CH₂Cl₂ / 0 °C

With lithium bromide; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;

DOI:10.1016/0040-4039(80)88099-3

Reference yield:

(1S,4R,5S)-5-Bromomethyl-5-methyl-6-methylene-bicyclo[2.2.1]hept-2-ene (78186-10-4) → ((1S,2S,3S,4R,5S)-2-Chloromethyl-3-methyl-5-phenylsulfanyl-tricyclo[2.2.1.02,6]hept-3-yl)-acetonitrile (78173-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hexamethylphosphoric acid triamide / 12 h / 120 °C

2: 85 percent / CH₂Cl₂ / 0 °C

In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;

DOI:10.1016/0040-4039(80)88099-3

upstream raw materials:

((1R,2S,4S)-2-Methyl-3-methylene-bicyclo[2.2.1]hept-5-en-2-yl)-acetonitrile

benzenesulfenyl chloride

(1S,4R,5S)-5-Bromomethyl-5-methyl-6-methylene-bicyclo[2.2.1]hept-2-ene

C₂₄H₂₈O₆S₂

Downstream raw materials:

((1S,2S,3S,4R,5S)-2-Chloromethyl-3-methyl-5-phenylsulfanyl-tricyclo[2.2.1.0^2,6]hept-3-yl)-acetaldehyde

2-((1R,2S,3R,4S,5R)-2,3-Dimethyl-5-phenylsulfanyl-tricyclo[2.2.1.0^2,6]hept-3-yl)-ethanol

2-((1R,2S,3R,4S,5R)-5-Benzenesulfonyl-2,3-dimethyl-tricyclo[2.2.1.0^2,6]hept-3-yl)-ethanol

3-((1R,2S,3R,4S,5R)-5-Benzenesulfonyl-2,3-dimethyl-tricyclo[2.2.1.0^2,6]hept-3-yl)-propionitrile

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 78173-28-1 ((1S,2S,3S,4R,5S)-2-Chloromethyl-3-methyl-5-phenylsulfanyl-tricyclo[2.2.1.0^2,6]hept-3-yl)-acetonitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send