Ethyl 2-(4-bromophenyl)-2-cyanoacetate

Base Information

Chemical Name:Ethyl 2-(4-bromophenyl)-2-cyanoacetate
CAS No.:39266-22-3
Molecular Formula:C₁₁H₁₀BrNO₂
Molecular Weight:268.11
Hs Code.:
DSSTox Substance ID:DTXSID601292727
Nikkaji Number:J1.751.380J

Synonyms:ethyl 2-(4-bromophenyl)-2-cyanoacetate;39266-22-3;ethyl2-(4-bromophenyl)-2-cyanoacetate;Benzeneacetic acid, 4-bromo-alpha-cyano-, ethyl ester;SCHEMBL13700788;DTXSID601292727;MFCD03412569;AKOS012173875;Ethyl 4-bromo-alpha-cyanobenzeneacetate;NS-04264;CS-0361403;alpha-Cyano-4-bromobenzeneacetic acid ethyl ester

Suppliers and Price of Ethyl 2-(4-bromophenyl)-2-cyanoacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Ethyl 2-(4-bromophenyl)-2-cyanoacetate

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:266.98949
Heavy Atom Count:15
Complexity:263

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(C#N)C1=CC=C(C=C1)Br

Technology Process of Ethyl 2-(4-bromophenyl)-2-cyanoacetate

There total 3 articles about Ethyl 2-(4-bromophenyl)-2-cyanoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 16532-79-9
4-Bromophenylacetonitrile

: 541-41-3
chloroformic acid ethyl ester

: 39266-22-3
ethyl α-(4-bromophenyl)-α-cyanoacetate

Guidance literature:: 4-Bromophenylacetonitrile; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 1.5h;

chloroformic acid ethyl ester; In tetrahydrofuran; at -78 ℃; for 16h;
DOI:10.1002/chem.201603082

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 105-56-6
ethyl 2-cyanoacetate

: 39266-22-3
ethyl α-(4-bromophenyl)-α-cyanoacetate

Guidance literature:: ethyl 2-cyanoacetate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

1.4-dibromobenzene; In tetrahydrofuran; at 0 ℃; for 8h; Inert atmosphere;
DOI:10.1039/c7ob01025g