1-acetyl-piperidine-4-carboxylic acid (3-chloro-4-methyl-phenyl)-[3-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-propyl]-amide

Base Information

• Chemical Name: 1-acetyl-piperidine-4-carboxylic acid (3-chloro-4-methyl-phenyl)-[3-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-propyl]-amide
• CAS No.: 872001-49-5
• Molecular Formula: C₂₄H₃₅ClN₄O₂
• Molecular Weight: 447.021

Synonyms:1-acetyl-piperidine-4-carboxylic acid (3-chloro-4-methyl-phenyl)-[3-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-propyl]-amide

Chemical Property of 1-acetyl-piperidine-4-carboxylic acid (3-chloro-4-methyl-phenyl)-[3-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-propyl]-amide

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Technology Process of 1-acetyl-piperidine-4-carboxylic acid (3-chloro-4-methyl-phenyl)-[3-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-propyl]-amide

There total 1 articles about 1-acetyl-piperidine-4-carboxylic acid (3-chloro-4-methyl-phenyl)-[3-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-propyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-acetyl-piperidine-4-carboxylic acid (3-chloro-4-methyl-phenyl)-[3-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-propyl]-amide (872001-49-5)

Guidance literature:

Reference yield: 90.0%

2-( tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid (872001-50-8) + 1-acetyl-piperidine-4-carboxylic acid (3-chloro-4-methyl-phenyl)-[3-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-propyl]-amide (872001-49-5) → C39H52ClN5O5

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 16h;

Reference yield:

1-acetyl-piperidine-4-carboxylic acid (3-chloro-4-methyl-phenyl)-[3-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-propyl]-amide (872001-49-5) + 2-pyrrolidin-1-yl-nicotinic acid (690632-36-1) → 1-acetyl-piperidine-4-carboxylic acid (3-chloro-4-methyl-phenyl)-{3-[5-(2-pyrrolidin-1-yl-pyridine-3-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-propyl}-amide trifluoro-acetate

Guidance literature:

2-pyrrolidin-1-yl-nicotinic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In acetonitrile; at 20 ℃; for 1h;

1-acetyl-piperidine-4-carboxylic acid (3-chloro-4-methyl-phenyl)-[3-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-propyl]-amide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;

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