2-Boc-1,2,3,4-Tetrahydroisoquinoline-5-Carboxylic Acid

Base Information

• Chemical Name: 2-Boc-1,2,3,4-Tetrahydroisoquinoline-5-Carboxylic Acid
• CAS No.: 872001-50-8
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.32
• Hs Code.: 2933499090
• Mol file: 872001-50-8.mol

Synonyms:QC-7293;3,4-Dihydro-1H-isoquinoline-2,5-dicarboxylic acid 2-tert-butyl ester;Boc-5-hydroxycarbonyl-1,2,3,4-tetrahydroisoquinoline;2-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-5-CARBOXYLIC ACID;

Chemical Property of 2-Boc-1,2,3,4-Tetrahydroisoquinoline-5-Carboxylic Acid

Chemical Property:

• Boiling Point: 432.5±45.0 °C(Predicted)
• PKA: 4.12±0.20(Predicted)
• PSA: 66.84000
• Density: 1?+-.0.06 g/cm3(Predicted)
• LogP: 2.61590
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-5-CARBOXYLICACID 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Boc-1,2,3,4-Tetrahydroisoquinoline-5-Carboxylic Acid

There total 1 articles about 2-Boc-1,2,3,4-Tetrahydroisoquinoline-5-Carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-tert-butyl 5-methyl 3,4-dihydroisoquinoline-2,5(1H)-dicarboxylate (1428327-32-5) → 2-( tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid (872001-50-8)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; Inert atmosphere;

DOI:10.1021/ml400040v

Reference yield: 100.0%

2-( tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid (872001-50-8) + benzylamine (100-46-9) → N-benzyl-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

Guidance literature:

2-( tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid; benzylamine; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 72h;

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 18h;

Reference yield: 90.0%

2-( tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid (872001-50-8) + 1-acetyl-piperidine-4-carboxylic acid (3-chloro-4-methyl-phenyl)-[3-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-propyl]-amide (872001-49-5) → C39H52ClN5O5

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 16h;

upstream raw materials:

2-tert-butyl 5-methyl 3,4-dihydroisoquinoline-2,5(1H)-dicarboxylate

Downstream raw materials:

tert-butyl 5-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

N-((1-(4-phenylpiperazin-1-yl)cyclohexyl)methyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide

2-methyl-N-((1-(4-phenylpiperazin-1-yl)cyclohexyl)methyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide

tert-butyl 5-(((1-(4-phenylpiperazin-1-yl)cyclohexyl)methyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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