tert-butyl 5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate

Base Information

Chemical Name:tert-butyl 5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate
CAS No.:1201644-55-4
Molecular Formula:C₃₀H₂₈N₆O₂
Molecular Weight:504.591
Hs Code.:

Synonyms:tert-butyl 5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate

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Chemical Property of tert-butyl 5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate

There total 21 articles about tert-butyl 5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1171897-39-4
tert-butyl (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)carbamate

: 1201643-72-2
2-(4-(3-acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

: 1201644-55-4
tert-butyl 5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 155 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 40119-34-4
2-methyl-2-(4-methylphenyl)propionitrile

: 1201644-55-4
tert-butyl 5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 12 steps

1.1: pyridine; potassium permanganate / water / 1 h / Reflux

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

3.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

3.2: 25 °C

4.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

5.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

6.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

7.1: hydrogenchloride / acetone / 24 h

8.1: hydrogenchloride / water / 24 h

9.1: potassium acetate / ethanol / 5 h / Reflux

10.1: hydrogenchloride; titanium(III) chloride

11.1: potassium acetate / toluene

12.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 0.5 h / 155 °C / Microwave irradiation

With pyridine; hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; potassium permanganate; titanium(III) chloride; oxalyl dichloride; potassium acetate; potassium carbonate; caesium carbonate; ozone; N,N-dimethyl-formamide; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 4-(1-cyano-1-methylethyl)benzoic acid chloride

: 1201644-55-4
tert-butyl 5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

1.2: 25 °C

2.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

3.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

4.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

5.1: hydrogenchloride / acetone / 24 h

6.1: hydrogenchloride / water / 24 h

7.1: potassium acetate / ethanol / 5 h / Reflux

8.1: hydrogenchloride; titanium(III) chloride

9.1: potassium acetate / toluene

10.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 0.5 h / 155 °C / Microwave irradiation

With hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; titanium(III) chloride; potassium acetate; potassium carbonate; caesium carbonate; ozone; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;