N-tert-Butyloxycarbonyl-L-phenylalanyl-L-serine ethyl ester

Base Information

• Chemical Name: N-tert-Butyloxycarbonyl-L-phenylalanyl-L-serine ethyl ester
• CAS No.: 123228-25-1
• Molecular Formula: C₁₉H₂₈N₂O₆
• Molecular Weight: 380.441
• Mol file: 123228-25-1.mol

Synonyms:N-tert-Butyloxycarbonyl-L-phenylalanyl-L-serine ethyl ester

Chemical Property of N-tert-Butyloxycarbonyl-L-phenylalanyl-L-serine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-tert-Butyloxycarbonyl-L-phenylalanyl-L-serine ethyl ester

There total 2 articles about N-tert-Butyloxycarbonyl-L-phenylalanyl-L-serine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + L-serine ethyl ester hydrochloride (26348-61-8,104055-46-1) → N-tert-Butyloxycarbonyl-L-phenylalanyl-L-serine ethyl ester (123228-25-1)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1039/a907483j

Reference yield: 33.0%

ethyl L-serinate (4117-31-1) + α-N-t-Boc-phenylalanyl ethyl phosphate → N-tert-Butyloxycarbonyl-L-phenylalanyl-L-serine ethyl ester (123228-25-1)

Guidance literature:

at 23 ℃; for 1h; pH=8; aq. phosphate buffer;

DOI:10.1039/c1ob05660c

Reference yield: 100.0%

N-tert-Butyloxycarbonyl-L-phenylalanyl-L-serine ethyl ester (123228-25-1) → (S)-2-((S)-2-(((tert-butoxy)carbonyl)amino)-3-phenylpropanamido)-3-hydroxypropanoic acid (123228-32-0)

Guidance literature:

With sodium hydroxide; water; In methanol; for 3h;

DOI:10.1039/a907483j

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

L-serine ethyl ester hydrochloride

ethyl L-serinate

Downstream raw materials:

(S)-2-((S)-2-(((tert-butoxy)carbonyl)amino)-3-phenylpropanamido)-3-hydroxypropanoic acid

N-Benzyl-(N-tert-butyloxycarbonyl-L-phenylalanyl)-L-serinamide

N-Benzyl-(N-tert-butyloxycarbonyl-L-phenylalanyl-DL-α-acetoxy)glycinamide