N-[1-((S)-3,5-dihydroxypentyl)piperidine-4-yl]-N-(4-fluorobenzyl)-2-(4-isobutoxyphenyl)acetamide

Base Information

Chemical Name:N-[1-((S)-3,5-dihydroxypentyl)piperidine-4-yl]-N-(4-fluorobenzyl)-2-(4-isobutoxyphenyl)acetamide
CAS No.:639862-77-4
Molecular Formula:C₂₉H₄₁FN₂O₄
Molecular Weight:500.654
Hs Code.:

Synonyms:N-[1-((S)-3,5-dihydroxypentyl)piperidine-4-yl]-N-(4-fluorobenzyl)-2-(4-isobutoxyphenyl)acetamide

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Chemical Property of N-[1-((S)-3,5-dihydroxypentyl)piperidine-4-yl]-N-(4-fluorobenzyl)-2-(4-isobutoxyphenyl)acetamide

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Technology Process of N-[1-((S)-3,5-dihydroxypentyl)piperidine-4-yl]-N-(4-fluorobenzyl)-2-(4-isobutoxyphenyl)acetamide

There total 7 articles about N-[1-((S)-3,5-dihydroxypentyl)piperidine-4-yl]-N-(4-fluorobenzyl)-2-(4-isobutoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 639861-41-9
N-(4-fluorobenzyl)-N-(piperidin-4-yl)-2-(4-isobutyloxyphenyl)acetamide

: 639863-97-1
(R)-5-[(4-methylbenzenesulfonyl)oxy]pentane-1,3-diol

: 639862-77-4
N-[1-((S)-3,5-dihydroxypentyl)piperidine-4-yl]-N-(4-fluorobenzyl)-2-(4-isobutoxyphenyl)acetamide

Guidance literature:: With potassium carbonate; sodium iodide; In DMF (N,N-dimethyl-formamide); at 60 ℃;

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 639862-77-4
N-[1-((S)-3,5-dihydroxypentyl)piperidine-4-yl]-N-(4-fluorobenzyl)-2-(4-isobutoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium cyanoborohydride; acetic acid / methanol / 20 h / 20 °C

2: triethylamine / dichloromethane / 3 h / 0 - 20 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

4: potassium carbonate; sodium iodide / DMF (N,N-dimethyl-formamide) / 60 °C

With hydrogen; sodium cyanoborohydride; potassium carbonate; acetic acid; triethylamine; sodium iodide; palladium 10% on activated carbon; In methanol; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane;

Reference yield:

: 639862-23-0
4-(4-fluorobenzylamino)-piperidine-1-carboxylic acid benzyl ester

: 639862-77-4
N-[1-((S)-3,5-dihydroxypentyl)piperidine-4-yl]-N-(4-fluorobenzyl)-2-(4-isobutoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

3: potassium carbonate; sodium iodide / DMF (N,N-dimethyl-formamide) / 60 °C

With hydrogen; potassium carbonate; triethylamine; sodium iodide; palladium 10% on activated carbon; In DMF (N,N-dimethyl-formamide); ethanol; dichloromethane;