N-benzyl-N-(1-cyclohexyl)-3-(phenylprop-2-ynyl)-hydroxylamine

Base Information

• Chemical Name: N-benzyl-N-(1-cyclohexyl)-3-(phenylprop-2-ynyl)-hydroxylamine
• CAS No.: 872470-62-7
• Molecular Formula: C₂₂H₂₅NO
• Molecular Weight: 319.447
• Mol file: 872470-62-7.mol

Synonyms:N-benzyl-N-(1-cyclohexyl)-3-(phenylprop-2-ynyl)-hydroxylamine

Chemical Property of N-benzyl-N-(1-cyclohexyl)-3-(phenylprop-2-ynyl)-hydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-benzyl-N-(1-cyclohexyl)-3-(phenylprop-2-ynyl)-hydroxylamine

There total 6 articles about N-benzyl-N-(1-cyclohexyl)-3-(phenylprop-2-ynyl)-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

phenylacetylene (536-74-3) + (Z)-N-(cyclohexylmethylene)-1-phenylmethanamine oxide (22687-06-5,309918-57-8) → N-benzyl-N-(1-cyclohexyl)-3-(phenylprop-2-ynyl)-hydroxylamine (872470-62-7)

Guidance literature:

With zinc trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 23 ℃; for 6h;

DOI:10.1021/ol052540c

Reference yield: 95.0%

N-cyclohexylidenebenzylamine N-oxide (22687-06-5) + phenylacetylene (536-74-3) → N-benzyl-N-(1-cyclohexyl)-3-(phenylprop-2-ynyl)-hydroxylamine (872470-62-7)

Guidance literature:

With In(hexamethyldisilazide)₂(trifluoromethanesulfonate); In tetrahydrofuran; at 25 ℃; for 18h;

DOI:10.1039/c4sc01332h

Reference yield:

syn-benzaldehyde oxime (932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2) → N-benzyl-N-(1-cyclohexyl)-3-(phenylprop-2-ynyl)-hydroxylamine (872470-62-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / NaBH₃CN; aq. HCl / methanol / 4 h / 25 °C

2: 88 percent / MgSO₄ / diethyl ether / 18 h

3: 95 percent / Zn(OTf)2; Huenig's base / CH₂Cl₂ / 6 h / 23 °C

With hydrogenchloride; zinc trifluoromethanesulfonate; sodium cyanoborohydride; magnesium sulfate; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane;

DOI:10.1021/ol052540c

upstream raw materials:

phenylacetylene

(Z)-N-(cyclohexylmethylene)-1-phenylmethanamine oxide

syn-benzaldehyde oxime

benzaldehyde

Downstream raw materials:

2-benzyl-3-cyclohexyl-5-phenyl-2,3-dihydroisoxazole