Benzenemethanamine, N-(cyclohexylmethylene)-, N-oxide

Base Information

• Chemical Name: Benzenemethanamine, N-(cyclohexylmethylene)-, N-oxide
• CAS No.: 22687-06-5
• Molecular Formula: C14H19NO
• Molecular Weight: 217.311
• Mol file: 22687-06-5.mol

Synonyms:

Chemical Property of Benzenemethanamine, N-(cyclohexylmethylene)-, N-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenemethanamine, N-(cyclohexylmethylene)-, N-oxide

There total 8 articles about Benzenemethanamine, N-(cyclohexylmethylene)-, N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-benzyl hydroxylalmine (622-30-0) + cyclohexanecarbaldehyde (2043-61-0) → N-cyclohexylidenebenzylamine N-oxide (22687-06-5)

Guidance literature:

With magnesium sulfate; at 20 ℃; for 5h;

DOI:10.1002/cjoc.201201168

Reference yield: 78.0%

N-benzylhydroxylamine hydrochloride (29601-98-7) + cyclohexanecarbaldehyde (2043-61-0) → N-cyclohexylidenebenzylamine N-oxide (22687-06-5)

Guidance literature:

In glycerol; at 60 - 80 ℃; for 0.666667h; Green chemistry;

DOI:10.1007/s12039-019-1677-7

Reference yield:

syn-benzaldehyde oxime (932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2) → (Z)-N-(cyclohexylmethylene)-1-phenylmethanamine oxide (22687-06-5,309918-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / NaBH₃CN; aq. HCl / methanol / 4 h / 25 °C

2: 88 percent / MgSO₄ / diethyl ether / 18 h

With hydrogenchloride; sodium cyanoborohydride; magnesium sulfate; In methanol; diethyl ether;

DOI:10.1021/ol052540c

upstream raw materials:

N-benzylhydroxylamine hydrochloride

cyclohexanecarbaldehyde

benzaldehyde

Benzaldoxime

Downstream raw materials:

C₂₁H₃₂NO₅P

N-benzyl-1-cyclohexyl-2-methylpropan-1-amine

N-benzyl-N-(1-cyclohexyl)-3-(phenylprop-2-ynyl)-hydroxylamine

N-benzyl-N-(1-cyclohexyl-4,4,4-trifluorobut-2-ynyl)hydroxylamine