7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydro-1(R,S)-naphthol

Base Information

Chemical Name:7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydro-1(R,S)-naphthol
CAS No.:204588-79-4
Molecular Formula:C₂₃H₂₄O₃
Molecular Weight:348.442
Hs Code.:

Synonyms:7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydro-1(R,S)-naphthol

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Chemical Property of 7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydro-1(R,S)-naphthol

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Technology Process of 7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydro-1(R,S)-naphthol

There total 8 articles about 7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydro-1(R,S)-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 204588-78-3
7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydronaphthalen-1-one

: 204588-79-4
7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydro-1(R,S)-naphthol

Guidance literature:: With sodium tetrahydroborate; In methanol; for 1h;
DOI:10.1016/S0968-0896(98)80017-5

Reference yield:

: 56663-76-4
2,2-dimethyl-3-butynoic acid

: 204588-79-4
7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydro-1(R,S)-naphthol

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / DCC; DMAP / CH₂Cl₂

2: 57 percent / triethylamine / PdCl₂(PPh₃)2 / dimethylformamide / 70 °C

3: 72 percent / sodium borohydride / methanol / 1 h

With dmap; sodium tetrahydroborate; triethylamine; dicyclohexyl-carbodiimide; bis-triphenylphosphine-palladium(II) chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: Esterification / 2: Condensation / 3: Reduction;
DOI:10.1016/S0968-0896(98)80017-5

Reference yield:

: 204588-77-2
2,2-dimethyl-3-butynoic acid benzyl ester

: 204588-79-4
7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydro-1(R,S)-naphthol

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / triethylamine / PdCl₂(PPh₃)2 / dimethylformamide / 70 °C

2: 72 percent / sodium borohydride / methanol / 1 h

With sodium tetrahydroborate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; N,N-dimethyl-formamide; 1: Condensation / 2: Reduction;
DOI:10.1016/S0968-0896(98)80017-5