7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydronaphthalen-1-one

Base Information

• Chemical Name: 7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydronaphthalen-1-one
• CAS No.: 204588-78-3
• Molecular Formula: C₂₃H₂₂O₃
• Molecular Weight: 346.426

Synonyms:7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydronaphthalen-1-one

Chemical Property of 7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydronaphthalen-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydronaphthalen-1-one

There total 6 articles about 7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydronaphthalen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

7-Trifluoromethanesulphonyloxy-1,2,3,4-tetrahydronaphthalen-1-one (144464-65-3) + 2,2-dimethyl-3-butynoic acid benzyl ester (204588-77-2) → 7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydronaphthalen-1-one (204588-78-3)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 70 ℃;

DOI:10.1016/S0968-0896(98)80017-5

Reference yield:

2,2-dimethyl-3-butynoic acid (56663-76-4) → 7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydronaphthalen-1-one (204588-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / DCC; DMAP / CH₂Cl₂

2: 57 percent / triethylamine / PdCl₂(PPh₃)2 / dimethylformamide / 70 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; N,N-dimethyl-formamide; 1: Esterification / 2: Condensation;

DOI:10.1016/S0968-0896(98)80017-5

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydronaphthalen-1-one (204588-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / DCC; DMAP / CH₂Cl₂

2: 57 percent / triethylamine / PdCl₂(PPh₃)2 / dimethylformamide / 70 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; N,N-dimethyl-formamide; 1: Esterification / 2: Condensation;

DOI:10.1016/S0968-0896(98)80017-5

upstream raw materials:

7-Trifluoromethanesulphonyloxy-1,2,3,4-tetrahydronaphthalen-1-one

2,2-dimethyl-3-butynoic acid benzyl ester

2,2-dimethyl-3-butynoic acid

benzyl alcohol

Downstream raw materials:

1-[7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose

7-[3-(benzyloxycarbonyl)-3,3-dimethyl-1-propynyl]-1,2,3,4-tetrahydro-1(R,S)-naphthol

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