(2E,4R,5R)-5-hydroxy-2--4-phenyl-2-heptenenitrile

Base Information

Chemical Name:(2E,4R,5R)-5-hydroxy-2--4-phenyl-2-heptenenitrile
CAS No.:147599-20-0
Molecular Formula:C₂₃H₂₈N₂O₂
Molecular Weight:364.488
Hs Code.:

(2E,4R,5R)-5-hydroxy-2-<N-methy-N-(2-hydroxy-1-methyl-2-phenylethyl)amino>-4-phenyl-2-heptenenitrile

Synonyms:(2E,4R,5R)-5-hydroxy-2--4-phenyl-2-heptenenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E,4R,5R)-5-hydroxy-2--4-phenyl-2-heptenenitrile

Chemical Property:

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Technology Process of (2E,4R,5R)-5-hydroxy-2--4-phenyl-2-heptenenitrile

There total 1 articles about (2E,4R,5R)-5-hydroxy-2--4-phenyl-2-heptenenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-38-6
propionaldehyde

: 2--4-phenyl-3-butenenitrile

: 147599-18-6
(2Z,4S,5R)-5-hydroxy-2--4-phenyl-2-heptenenitrile

: (2Z,4S,5S)-5-hydroxy-2--4-phenyl-2-heptenenitrile

: 147599-20-0
(2E,4R,5R)-5-hydroxy-2--4-phenyl-2-heptenenitrile

: 147471-37-2
(2Z,4R,5S)-5-hydroxy-2--4-phenyl-2-heptenenitrile

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given; 1) THF, -78 deg C, 2) THF, -78 deg C, 1 h;
DOI:10.1021/jo00059a027

Reference yield:

: 147599-20-0
(2E,4R,5R)-5-hydroxy-2--4-phenyl-2-heptenenitrile

: 147599-27-7
(4R,5R)-(-)-4,5-dihydro-5-ethyl-4-phenyl-(3H)-furan-2-one

Guidance literature:: With oxalic acid; In tetrahydrofuran; at 100 ℃; for 12h;
DOI:10.1021/jo00059a027

Reference yield:

: 147599-20-0
(2E,4R,5R)-5-hydroxy-2--4-phenyl-2-heptenenitrile

: 147471-46-3
Methanesulfonic acid (1R,2R)-1-ethyl-4-methanesulfonyloxy-2-phenyl-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. oxalic acid / tetrahydrofuran / 12 h / 100 °C

2: 1) BH₃*SMe₂, 2) glycerin, H₂₀ / 1) THF, 100 deg C, 2) THF, reflux

3: Et₃N / CH₂Cl₂

With dimethylsulfide borane complex; water; oxalic acid; triethylamine; glycerol; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00059a027