(4S)-5-(4-fluorophenyl)-6-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-3,4-dihydro-spiro[chromen-2,1'-cyclobutan]-4-ol

Base Information

Chemical Name:(4S)-5-(4-fluorophenyl)-6-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-3,4-dihydro-spiro[chromen-2,1'-cyclobutan]-4-ol
CAS No.:950673-88-8
Molecular Formula:C₂₉H₂₇F₅O₂
Molecular Weight:502.524
Hs Code.:

Synonyms:(4S)-5-(4-fluorophenyl)-6-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-3,4-dihydro-spiro[chromen-2,1'-cyclobutan]-4-ol

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Chemical Property of (4S)-5-(4-fluorophenyl)-6-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-3,4-dihydro-spiro[chromen-2,1'-cyclobutan]-4-ol

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Technology Process of (4S)-5-(4-fluorophenyl)-6-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-3,4-dihydro-spiro[chromen-2,1'-cyclobutan]-4-ol

There total 2 articles about (4S)-5-(4-fluorophenyl)-6-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-3,4-dihydro-spiro[chromen-2,1'-cyclobutan]-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: C₃₆H₄₁F₅O₂Si

: 950673-88-8
(4S)-5-(4-fluorophenyl)-6-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-3,4-dihydro-spiro[chromen-2,1'-cyclobutan]-4-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2010.10.110

Reference yield: 43.0%

: 950674-75-6
5-(4-fluorophenyl)-6-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one

: 950673-89-9
(4S)-5-(4-fluorophenyl)-6-{(R)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-3,4-dihydro-spiro[chromen-2,1'-cyclobutan]-4-ol

: 950673-88-8
(4S)-5-(4-fluorophenyl)-6-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-3,4-dihydro-spiro[chromen-2,1'-cyclobutan]-4-ol

Guidance literature:: 5-(4-fluorophenyl)-6-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropylspiro[chromen-2,1'-cyclobutan]-4(3H)-one; With borane N,N-diethylaniline complex; (1R,2S)-1-Amino-2-indanol; In tetrahydrofuran; at 20 ℃; for 6.16667h; Inert atmosphere;

With methanol; In tetrahydrofuran; for 0.25h;