SULFACHLOROPYRIDAZINE

Base Information

• Chemical Name: SULFACHLOROPYRIDAZINE
• CAS No.: 80-32-0
• Molecular Formula: C10H9 Cl N4 O2 S
• Molecular Weight: 284.726
• Hs Code.: 2935909550
• European Community (EC) Number: 201-269-9
• NSC Number: 757858
• UNII: P78D9P90C0
• DSSTox Substance ID: DTXSID9045265
• Nikkaji Number: J5.242F
• Wikipedia: Sulfachlorpyridazine
• Wikidata: Q27126423
• NCI Thesaurus Code: C76974
• RXCUI: 2476008
• Metabolomics Workbench ID: 60379
• ChEMBL ID: CHEMBL1443577
• Mol file: 80-32-0.mol

Synonyms:Sulfanilamide,N1-(6-chloro-3-pyridazinyl)- (6CI,7CI,8CI); 3-Chloro-6-sulfanilamidopyridazine;6-Sulfanilamido-3-chloropyridazine; BA 10370; Bactolin; Ciba 10370; Consulid;Cosulid; Durasulf; N1-(6-Chloro-3-pyridazinyl)sulfanilamide; Nefrosul;Renalsulfa; Sonilyn; Sulfachlorpyridazine; Sulfaclorazina; Sulfarene;Sulfochlorpyridazine; Sulpirazina

Chemical Property of SULFACHLOROPYRIDAZINE

Chemical Property:

• Melting Point: 186-187oC
• Refractive Index: 1.6300 (estimate)
• Boiling Point: 559.7 °C at 760 mmHg
• PKA: pKa 6.10 (Uncertain)
• Flash Point: 292.3 °C
• PSA: 106.35000
• Density: 1.588 g/cm³
• LogP: 3.24800
• Storage Temp.: 0-6°C
• Solubility.: 0.5 M NaOH: soluble50mg/mL
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 284.0134744
• Heavy Atom Count: 18
• Complexity: 365

Purity/Quality:

99% ^*data from raw suppliers

Sulfachlorpyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1N)S(=O)(=O)NC2=NN=C(C=C2)Cl
• Description: It is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood. Specifically, due to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.1 Moreover, this substance can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.2 In addition, this compound can act as an eco-friendly inhibitor for corrosion of mild steel in H2SO4 solution.3 Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.4
• Uses: Antibacterial compound. Sulfachloropyridazine is an antibacterial compound.This compound is a contaminant of emerging concern (CECs).
• Therapeutic Function: Antibacterial

Technology Process of SULFACHLOROPYRIDAZINE

There total 5 articles about SULFACHLOROPYRIDAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,6-dichlorpyridazine (141-30-0) + sulfanilamide (63-74-1) → sulfachloropyridazine (80-32-0)

Guidance literature:

With potassium carbonate; sodium chloride;

DOI:10.1002/hlca.19540370115

Reference yield:

[4-(6-chloro-pyridazin-3-ylsulfamoyl)-phenyl]-carbamic acid ethyl ester → sulfachloropyridazine (80-32-0)

Guidance literature:

With sodium hydroxide;

DOI:10.1002/hlca.19540370115

Reference yield:

4-acetylamino-N-(6-chloro-pyridazin-3-yl)-benzenesulfonamide (4489-33-2) → sulfachloropyridazine (80-32-0)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

3,6-dichlorpyridazine

sulfanilamide

4-acetylamino-N-(6-chloro-pyridazin-3-yl)-benzenesulfonamide

ethyl 4-(chlorosulfonyl)phenylcarbamate

Downstream raw materials:

C₂₁H₂₄ClN₅O₃S

C₃₀H₃₂Cl₂N₆O₂S

Refernces