3-benzenesulfonyl-6,7-dimethoxy-5-methyl-2,3-dihydro-1H-benzo[d]azepine

Base Information

Chemical Name:3-benzenesulfonyl-6,7-dimethoxy-5-methyl-2,3-dihydro-1H-benzo[d]azepine
CAS No.:1414943-14-8
Molecular Formula:C₁₉H₂₁NO₄S
Molecular Weight:359.446
Hs Code.:

Synonyms:3-benzenesulfonyl-6,7-dimethoxy-5-methyl-2,3-dihydro-1H-benzo[d]azepine

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Chemical Property of 3-benzenesulfonyl-6,7-dimethoxy-5-methyl-2,3-dihydro-1H-benzo[d]azepine

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Technology Process of 3-benzenesulfonyl-6,7-dimethoxy-5-methyl-2,3-dihydro-1H-benzo[d]azepine

There total 4 articles about 3-benzenesulfonyl-6,7-dimethoxy-5-methyl-2,3-dihydro-1H-benzo[d]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1414943-06-8
N-{2-[3,4-dimethoxy-2-(1-methylallyl)phenyl]ethyl}benzenesulfonamide

: 1414943-14-8
3-benzenesulfonyl-6,7-dimethoxy-5-methyl-2,3-dihydro-1H-benzo[d]azepine

Guidance literature:: N-{2-[3,4-dimethoxy-2-(1-methylallyl)phenyl]ethyl}benzenesulfonamide; With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; at 20 ℃; for 2h; Inert atmosphere;

With sodium periodate; In tetrahydrofuran; water; at 20 ℃; for 1h; Inert atmosphere;

With acetic acid; In tetrahydrofuran; water; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2012.10.017

Reference yield:

: 1414942-98-5
1,2-dimethoxy-3-(1-methylallyl)-4-(2-nitrovinyl)benzene

: 1414943-14-8
3-benzenesulfonyl-6,7-dimethoxy-5-methyl-2,3-dihydro-1H-benzo[d]azepine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

2.1: potassium carbonate / dichloromethane / 4 h / 20 °C / Inert atmosphere

3.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

3.3: 1 h / 20 °C / Inert atmosphere

With osmium(VIII) oxide; lithium aluminium tetrahydride; potassium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2012.10.017

Reference yield:

: 374073-50-4
3,4-dimethoxy-2-(1-methylprop-2-enyl)benzaldehyde

: 1414943-14-8
3-benzenesulfonyl-6,7-dimethoxy-5-methyl-2,3-dihydro-1H-benzo[d]azepine

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate / Reflux; Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

3.1: potassium carbonate / dichloromethane / 4 h / 20 °C / Inert atmosphere

4.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere

4.2: 1 h / 20 °C / Inert atmosphere

4.3: 1 h / 20 °C / Inert atmosphere

With osmium(VIII) oxide; lithium aluminium tetrahydride; ammonium acetate; potassium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; water; 1.1: |Henry Nitro Aldol Condensation;
DOI:10.1016/j.tet.2012.10.017