374073-50-4

Upstream product

• 374073-47-9 3-hydroxy-4-methoxy-2-(1-methylprop-2-enyl)benzaldehyde 
• 267898-02-2 (E)-3-(But-2-enyloxy)-4-methoxybenzaldehyde 
• 74-83-9 methyl bromide 
• 74-88-4 methyl iodide 
• 621-59-0 isovanillin 

Downstream Products

• 494798-08-2 3,4-dimethoxy-2-(1-methylallyl)benzyl alcohol 
• 1370593-44-4 [3,4-dimethoxy-2-(1-methyl-allyl)-phenyl]-phenyl-methanone 
• 1380515-56-9 C₁₄H₁₈O₃ 
• 1420805-24-8 3,4-dimethoxy-2-(3-oxobutan-2-yl)benzaldehyde 
• 1414943-14-8 3-benzenesulfonyl-6,7-dimethoxy-5-methyl-2,3-dihydro-1H-benzo[d]azepine 
• 1414943-06-8 N-{2-[3,4-dimethoxy-2-(1-methylallyl)phenyl]ethyl}benzenesulfonamide 
• 1414942-92-9 3-benzenesulfonyl-8,9-dimethoxy-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine 
• 1391762-28-9 3-[3,4-dimethoxy-2-(1-methyl-allyl)phenyl]-1,5-diphenylpentane-1,5-dione 

Relevant academic research and scientific papers

TBuO 2H/Cu(acac) 2-Mediated Intramolecular Oxidative Lactonization of o -Allyl Arylaldehydes: Synthesis of 1-Oxoisochromans

A concise route for the tBuO 2H/Cu(acac) 2-mediated synthesis of 1-oxoisochromans is described. This includes: (i) oxidation of oxygenated o -allyl arylaldehydes and (ii) sequential intramolecular lactonization of the resulting olefin-containing benzoic acids. A plausible mechanism is proposed and discussed.

CuI Mediated One-Pot Cycloacetalization/Ketalization of o-Carbonyl Allylbenzenes: Synthesis of Benzobicyclo[3.2.1]octane Core

CuI/DMSO-mediated intramolecular cycloacetalization/ketalization of o-carbonyl allylbenzenes has been achieved for constructing [6,6,5]-tricycles having a ketal motif in good yields. The expeditious one-step route provides a three C-O bond formation. The key products with the structural framework of a benzofused dioxabicyclo[3.2.1]octane core have been confirmed by X-ray crystallographic analysis. Synthesis of dihydroisocoumarin has been studied.

Synthesis of substituted indenes from isovanillin via claisen rearrangement and ring-closing metathesis

A new synthesis of substituted indenes was studied. Based on Claisen rearrangement,Wittig reaction and ring-closing metathesis (RCM), a series of substituted indenes was synthesized from isovanillin in good yields.

One-pot access to 2-naphthols and benzofurans via the aerobic Wacker-type oxidation/intramolecular aldol cyclization

An aerobic Wacker-type oxidation/intramolecular aldol cyclization synthetic route toward two oxygenated 2-naphthols 3 and benzofurans 4 starting with skeleton 2 with good yields is described. The route has been carried by the one-pot transformation of the regioselective PdCl2/CuCl 2-mediated Wacker oxidative cyclization of skeleton 2 with molecular oxygen under the alkaline methanolic condition. Skeleton 2 was prepared from skeleton 1 in moderate total yields via the known protocol.

Synthesis of tetrahydroanthracen-9-ones by the domino aldol condensation/Diels-Alder cycloaddition

A facile protocol toward several substituted 3-aryl-3,4,4a,10-tetrahydro- 2H-anthracen-9-ones 1 starting with substituted 2-allylbenzaldehydes 2 was described. The overall synthetic process was carried out by the domino aldol condensation/Diels-Alder cycloaddition of skeleton 2 with substituted cinnamaldehydes 3 in an alkalic aqueous-methanolic solution followed by base-induced double migration of the resulting cycloadducts. Skeleton 2 was prepared from isovanillin (4) in moderate yield in five-steps via the known procedures with the synthetic sequence of O-allylation, Claisen rearrangement, O-methylation, Grignard methylation, and PCC-mediated oxidation.

Syntheses of substituted naphthalenes and naphthols

Syntheses of substituted naphthalenes and naphthols are described. Based on Claisen rearrangement, ring-closing metathesis (RCM), and related reactions, isovanillin was successfully transformed into a series of substituted naphthalenes and naphthols with

Synthesis of substituted indenes from isovanillin via claisen rearrangement and ring-closing metathesis

A new synthesis of substituted indenes was studied. Based on Claisen rearrangement, Wittig reaction and ring-closing metathesis (RCM), a series of substituted indenes was synthesized from isovanillin in good yields.

A synthesis of substituted 3,6-dihydro-1H-benzo[c]oxocines via Claisen rearrangement and ring-closing metathesis

Started from isovanillin, based on Claisen rearrangement and ring-closing metathesis (RCM) reaction, a series of substituted 3,6-dihydro-1H-benzo[c]oxocines were synthesized in moderate yields.

A novel synthesis of substituted naphthalenes via Claisen rearrangement and RCM reaction

A novel synthesis of substituted naphthalenes was studied. Starting from isovanillin, basing on Claisen rearrangement and ring-closing metathesis (RCM), a series of 1-alkoxy-2-methoxynaphthalenes and 1-alkoxy-2-methoxy-8-methylnaphthalenes together with a