S-methyl N-[4-chloro-3 (trifluoromethyl)phenyl]isothiourea hydroiodide

Base Information

• Chemical Name: S-methyl N-[4-chloro-3 (trifluoromethyl)phenyl]isothiourea hydroiodide
• CAS No.: 877874-55-0
• Molecular Formula: C₉H₈ClF₃N₂S*HI
• Molecular Weight: 396.603
• Mol file: 877874-55-0.mol

Synonyms:S-methyl N-[4-chloro-3 (trifluoromethyl)phenyl]isothiourea hydroiodide

Chemical Property of S-methyl N-[4-chloro-3 (trifluoromethyl)phenyl]isothiourea hydroiodide

Chemical Property:

Purity/Quality:

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Technology Process of S-methyl N-[4-chloro-3 (trifluoromethyl)phenyl]isothiourea hydroiodide

There total 1 articles about S-methyl N-[4-chloro-3 (trifluoromethyl)phenyl]isothiourea hydroiodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-chloro-3-trifluoromethyl-phenyl)-thiourea (207919-03-7) + methyl iodide (74-88-4) → S-methyl N-[4-chloro-3 (trifluoromethyl)phenyl]isothiourea hydroiodide (877874-55-0)

Guidance literature:

In methanol; for 12h; Heating / reflux;

Reference yield: 50.5%

4-(2,6-diamino-pyrimidin-4-yloxy)-benzoic acid hydrazide + S-methyl N-[4-chloro-3 (trifluoromethyl)phenyl]isothiourea hydroiodide (877874-55-0) → 6-{4-[5-(4-chloro-3-trifluoromethyl-phenylamino)-4H-[1,2,4]triazol-3-yl]-phenoxy}-pyrimidine-2,4-diamine

Guidance literature:

With pyridine; for 18h; Heating / reflux;

Reference yield: 40.4%

S-methyl N-[4-chloro-3 (trifluoromethyl)phenyl]isothiourea hydroiodide (877874-55-0) + 4-hydroxybenzoic acid hydrazide (5351-23-5) → 4-[5-(4-chloro-3-trifluoromethyl-phenylamino)-4H-[1,2,4]triazol-3-yl]-phenol (877874-56-1)

Guidance literature:

With pyridine; for 18h; Heating / reflux;

upstream raw materials:

(4-chloro-3-trifluoromethyl-phenyl)-thiourea

methyl iodide

Downstream raw materials:

3-[5-(4-chloro-3-trifluoromethyl-phenylamino)-4H-[1,2,4]triazol-3-yl]-phenol

4-[5-(4-chloro-3-trifluoromethyl-phenylamino)-4H-[1,2,4]triazol-3-yl]-phenol

(4-chloro-3-trifluoromethyl-phenyl)-{5-[4-(pyridin-3-yloxy)-phenyl]-4H-[1,2,4]triazol-3-yl}-amine