benzyl (1-{[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}cyclobutyl)carbamate

Base Information

Chemical Name:benzyl (1-{[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}cyclobutyl)carbamate
CAS No.:1616347-70-6
Molecular Formula:C₂₁H₁₉F₆NO₃
Molecular Weight:447.377
Hs Code.:

Synonyms:benzyl (1-{[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}cyclobutyl)carbamate

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Chemical Property of benzyl (1-{[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}cyclobutyl)carbamate

Chemical Property:

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Technology Process of benzyl (1-{[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}cyclobutyl)carbamate

There total 4 articles about benzyl (1-{[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616347-69-3
benzyl (1-{[3,5-bis(trifluoromethyl)phenyl]carbonyl}cyclobutyl)carbamate

: 1616347-70-6
benzyl (1-{[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}cyclobutyl)carbamate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -70 ℃; for 1h; Inert atmosphere;

Reference yield:

: 112981-69-8
3,5-bis(trifluoromethyl)phenylmagnesium bromide

: 1616347-70-6
benzyl (1-{[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 5 h / -20 - 20 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -70 °C / Inert atmosphere

With lithium aluminium tetrahydride; In tetrahydrofuran;

Reference yield:

: 190004-53-6
1-(((benzyloxy)carbonyl)amino)cyclobutane-1-carboxylic acid

: 1616347-70-6
benzyl (1-{[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl}cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; HATU / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 5 h / -20 - 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -70 °C / Inert atmosphere

With lithium aluminium tetrahydride; triethylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;