(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide hydrochloride

Base Information

Chemical Name:(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide hydrochloride
CAS No.:1363359-94-7
Molecular Formula:C₂₉H₃₃ClFN₅O₂*ClH
Molecular Weight:574.526
Hs Code.:

Synonyms:(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide hydrochloride

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Chemical Property of (E)-N-[4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide hydrochloride

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Technology Process of (E)-N-[4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide hydrochloride

There total 8 articles about (E)-N-[4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 13991-37-2
trans-2-pentenoic acid

N⁴-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine: 1363359-84-5
N⁴-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine

: 1363359-94-7
(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide hydrochloride

Guidance literature:: trans-2-pentenoic acid; N⁴-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

With hydrogenchloride; In methanol; water; at 20 ℃; for 2h;

Reference yield:

: 446-32-2
4-fluoroanthranilic acid

: 1363359-94-7
(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / 2-methoxy-ethanol / Reflux

2.1: nitric acid; sulfuric acid

3.1: thionyl chloride

4.1: isopropyl alcohol

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Cooling with ice

5.2: 20 °C / Inert atmosphere

6.1: acetic acid; iron / ethanol / 12 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C

7.2: 2 h / 20 °C

With thionyl chloride; sulfuric acid; nitric acid; iron; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethanol; 2-methoxy-ethanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1363360-02-4
(7-methyl-7-azaspiro[3.5]nonan-2-yl)methanol

: 1363359-94-7
(E)-N-[4-(3-chloro-4-fluorophenylamino)-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 20 °C / Inert atmosphere

2.1: acetic acid; iron / ethanol / 12 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C

3.2: 2 h / 20 °C

With iron; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethanol; N,N-dimethyl-formamide;