benzyl 4-{[1-(4-fluorophenyl)cyclopentyl]carbamoyl}piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 4-{[1-(4-fluorophenyl)cyclopentyl]carbamoyl}piperidine-1-carboxylate
CAS No.:1356861-76-1
Molecular Formula:C₂₅H₂₉FN₂O₃
Molecular Weight:424.515
Hs Code.:

Synonyms:benzyl 4-{[1-(4-fluorophenyl)cyclopentyl]carbamoyl}piperidine-1-carboxylate

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Chemical Property of benzyl 4-{[1-(4-fluorophenyl)cyclopentyl]carbamoyl}piperidine-1-carboxylate

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Technology Process of benzyl 4-{[1-(4-fluorophenyl)cyclopentyl]carbamoyl}piperidine-1-carboxylate

There total 5 articles about benzyl 4-{[1-(4-fluorophenyl)cyclopentyl]carbamoyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 214262-99-4
1-(4-fluorophenyl)-1-cyclopentanecarboxylic acid

: 1356861-76-1
benzyl 4-{[1-(4-fluorophenyl)cyclopentyl]carbamoyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: diphenylphosphoranyl azide; triethylamine / toluene / 24 h / 100 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4 h / 20 °C

3: triethylamine / dichloromethane / 24 h / 20 °C / Cooling with ice

With palladium 10% on activated carbon; diphenylphosphoranyl azide; hydrogen; triethylamine; In dichloromethane; ethyl acetate; toluene; 1: Curtius rearrangement;
DOI:10.1248/cpb.59.1376

Reference yield:

: 83706-50-7
1-(4-fluorophenyl)cyclopentane-1-carbonitrile

: 1356861-76-1
benzyl 4-{[1-(4-fluorophenyl)cyclopentyl]carbamoyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; water / 5 h / 150 °C

2: diphenylphosphoranyl azide; triethylamine / toluene / 24 h / 100 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4 h / 20 °C

4: triethylamine / dichloromethane / 24 h / 20 °C / Cooling with ice

With sulfuric acid; palladium 10% on activated carbon; diphenylphosphoranyl azide; water; hydrogen; triethylamine; In dichloromethane; ethyl acetate; toluene; 2: Curtius rearrangement;
DOI:10.1248/cpb.59.1376

Reference yield:

: 459-22-3
4-fluorophenylacetonitrile

: 1356861-76-1
benzyl 4-{[1-(4-fluorophenyl)cyclopentyl]carbamoyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 20 °C / Cooling with ice

2: sulfuric acid; water / 5 h / 150 °C

3: diphenylphosphoranyl azide; triethylamine / toluene / 24 h / 100 °C

4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4 h / 20 °C

5: triethylamine / dichloromethane / 24 h / 20 °C / Cooling with ice

With sulfuric acid; palladium 10% on activated carbon; diphenylphosphoranyl azide; water; hydrogen; sodium hydride; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil; 3: Curtius rearrangement;
DOI:10.1248/cpb.59.1376