[2-(2-hydroxyphenyl)ethyl]carbamic acid ethyl ester

Base Information

• Chemical Name: [2-(2-hydroxyphenyl)ethyl]carbamic acid ethyl ester
• CAS No.: 608519-05-7
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.245
• Mol file: 608519-05-7.mol

Synonyms:[2-(2-hydroxyphenyl)ethyl]carbamic acid ethyl ester

Chemical Property of [2-(2-hydroxyphenyl)ethyl]carbamic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(2-hydroxyphenyl)ethyl]carbamic acid ethyl ester

There total 5 articles about [2-(2-hydroxyphenyl)ethyl]carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[2-(2-benzyloxyphenyl)ethyl]carbamic acid ethyl ester (608519-04-6) → [2-(2-hydroxyphenyl)ethyl]carbamic acid ethyl ester (608519-05-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 2h; under 760 Torr;

DOI:10.1016/S0040-4020(03)01073-1

Reference yield:

3-(2'-(Benzyloxy)phenyl)propionic Acid (48179-00-6) → [2-(2-hydroxyphenyl)ethyl]carbamic acid ethyl ester (608519-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diphenylphosphoryl azide; Et₃N / toluene / 1 h / Heating

1.2: 94 percent / CuCl₂ / toluene / 1 h / Heating

2.1: 100 percent / H₂ / Pd/C / ethyl acetate / 2 h / 20 °C / 760 Torr

With diphenylphosphoranyl azide; hydrogen; triethylamine; palladium on activated charcoal; In ethyl acetate; toluene; 1.2: Curtius rearrangement;

DOI:10.1016/S0040-4020(03)01073-1

Reference yield:

C6H4(CH2CH2C(O)O) (119-84-6,1341-36-2) → [2-(2-hydroxyphenyl)ethyl]carbamic acid ethyl ester (608519-05-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 96 percent / tetrahydrofuran; H₂O / 0.5 h / 20 °C

2.1: 100 percent / tetrabutylammonium bromide; NaH / tetrahydrofuran / 1 h / 20 °C

3.1: 93 percent / aq. KOH / ethanol / 22 h / Heating

4.1: diphenylphosphoryl azide; Et₃N / toluene / 1 h / Heating

4.2: 94 percent / CuCl₂ / toluene / 1 h / Heating

5.1: 100 percent / H₂ / Pd/C / ethyl acetate / 2 h / 20 °C / 760 Torr

With potassium hydroxide; diphenylphosphoranyl azide; tetrabutylammomium bromide; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; ethyl acetate; toluene; 4.2: Curtius rearrangement;

DOI:10.1016/S0040-4020(03)01073-1

upstream raw materials:

[2-(2-benzyloxyphenyl)ethyl]carbamic acid ethyl ester

3-(2'-(Benzyloxy)phenyl)propionic Acid

C₆H₄(CH₂CH₂C(O)O)

N,N-dimethyl-3-(2-hydroxyphenyl)propionamide

Downstream raw materials:

trifluoromethanesulfonic acid 2-(2-ethoxycarbonylamino-ethyl)phenyl ester