(2E)-4-{2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazol-4-yl}but-2-en-1-ol

Base Information

Chemical Name:(2E)-4-{2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazol-4-yl}but-2-en-1-ol
CAS No.:292073-47-3
Molecular Formula:C₂₇H₃₅NO₂SSi
Molecular Weight:465.732
Hs Code.:

Synonyms:(2E)-4-{2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazol-4-yl}but-2-en-1-ol

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Chemical Property of (2E)-4-{2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazol-4-yl}but-2-en-1-ol

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Technology Process of (2E)-4-{2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazol-4-yl}but-2-en-1-ol

There total 9 articles about (2E)-4-{2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazol-4-yl}but-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 82994-41-0,81925-29-3,74141-12-1,74141-13-2
(E)-3-(tri-n-butylstannyl)-2-propen-1-ol

: 292073-43-9
4-bromomethyl-2-[(2-tert-butyldimethylsilyloxy)-1,1-dimethylethyl]thiazole

: 292073-47-3
(2E)-4-{2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazol-4-yl}but-2-en-1-ol

Guidance literature:: With dichloro bis(acetonitrile) palladium(II); In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.166667h;
DOI:10.1016/S0040-4020(03)01020-2

Reference yield:

: 14002-80-3
Methyl 2,2-dimethyl-3-hydroxypropionate

: 292073-47-3
(2E)-4-{2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazol-4-yl}but-2-en-1-ol

Guidance literature:: Multi-step reaction with 9 steps

1: imidazole / dimethylformamide / 14 h / 20 °C

2: DIBAL / diethyl ether; hexane / 0.5 h / -78 °C

3: Et₃N; pyridine*SO₃; DMSO / CH₂Cl₂ / 0.33 h / 20 °C

4: 16.8 g / Et₃N / toluene / 12 h / 20 °C

5: 62 percent / chemical manganese dioxide; pyridine / benzene / 12 h / Heating

6: 91 percent / DIBAL / diethyl ether; hexane / 0.5 h / -78 °C

7: Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

8: 344 mg / LiBr / acetone; CH₂Cl₂ / 1 h / 20 °C

9: 94 percent / Pd(CH₃CN)2Cl₂ / 1-methyl-pyrrolidin-2-one / 0.17 h / 20 °C

With pyridine; 1H-imidazole; manganese(IV) oxide; dichloro bis(acetonitrile) palladium(II); sulfur trioxide pyridine complex; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; lithium bromide; In 1-methyl-pyrrolidin-2-one; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; benzene; 3: Parikh-Doering oxidation;
DOI:10.1016/S0040-4020(03)01020-2

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 292073-47-3
(2E)-4-{2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazol-4-yl}but-2-en-1-ol

Guidance literature:: Multi-step reaction with 9 steps

1: imidazole / dimethylformamide / 14 h / 20 °C

2: DIBAL / diethyl ether; hexane / 0.5 h / -78 °C

3: Et₃N; pyridine*SO₃; DMSO / CH₂Cl₂ / 0.33 h / 20 °C

4: 16.8 g / Et₃N / toluene / 12 h / 20 °C

5: 62 percent / chemical manganese dioxide; pyridine / benzene / 12 h / Heating

6: 91 percent / DIBAL / diethyl ether; hexane / 0.5 h / -78 °C

7: Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

8: 344 mg / LiBr / acetone; CH₂Cl₂ / 1 h / 20 °C

9: 94 percent / Pd(CH₃CN)2Cl₂ / 1-methyl-pyrrolidin-2-one / 0.17 h / 20 °C

With pyridine; 1H-imidazole; manganese(IV) oxide; dichloro bis(acetonitrile) palladium(II); sulfur trioxide pyridine complex; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; lithium bromide; In 1-methyl-pyrrolidin-2-one; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; benzene; 3: Parikh-Doering oxidation;
DOI:10.1016/S0040-4020(03)01020-2