4-((2E)-4-bromobut-2-enyl)-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazole

Base Information

Chemical Name:4-((2E)-4-bromobut-2-enyl)-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazole
CAS No.:292073-48-4
Molecular Formula:C₂₇H₃₄BrNOSSi
Molecular Weight:528.629
Hs Code.:

Synonyms:4-((2E)-4-bromobut-2-enyl)-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazole

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Chemical Property of 4-((2E)-4-bromobut-2-enyl)-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazole

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Technology Process of 4-((2E)-4-bromobut-2-enyl)-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazole

There total 12 articles about 4-((2E)-4-bromobut-2-enyl)-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 292073-47-3
(2E)-4-{2-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazol-4-yl}but-2-en-1-ol

: 292073-48-4
4-((2E)-4-bromobut-2-enyl)-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazole

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/S0040-4020(03)01020-2

Reference yield:

: 14002-80-3
Methyl 2,2-dimethyl-3-hydroxypropionate

: 292073-48-4
4-((2E)-4-bromobut-2-enyl)-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazole

Guidance literature:: Multi-step reaction with 10 steps

1: imidazole / dimethylformamide / 14 h / 20 °C

2: DIBAL / diethyl ether; hexane / 0.5 h / -78 °C

3: Et₃N; pyridine*SO₃; DMSO / CH₂Cl₂ / 0.33 h / 20 °C

4: 16.8 g / Et₃N / toluene / 12 h / 20 °C

5: 62 percent / chemical manganese dioxide; pyridine / benzene / 12 h / Heating

6: 91 percent / DIBAL / diethyl ether; hexane / 0.5 h / -78 °C

7: Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

8: 344 mg / LiBr / acetone; CH₂Cl₂ / 1 h / 20 °C

9: 94 percent / Pd(CH₃CN)2Cl₂ / 1-methyl-pyrrolidin-2-one / 0.17 h / 20 °C

10: 95 percent / CBr₄; Ph₃P / CH₂Cl₂ / 0 - 20 °C

With pyridine; 1H-imidazole; manganese(IV) oxide; dichloro bis(acetonitrile) palladium(II); carbon tetrabromide; sulfur trioxide pyridine complex; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine; lithium bromide; In 1-methyl-pyrrolidin-2-one; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; benzene; 3: Parikh-Doering oxidation;
DOI:10.1016/S0040-4020(03)01020-2

Reference yield:

: 136022-55-4
3-((tert-butyldiphenylsilyl)oxy)-2,2-dimethylpropanal

: 292073-48-4
4-((2E)-4-bromobut-2-enyl)-[2-(tert-butyldiphenylsilyloxy)-1,1-dimethylethyl]thiazole

Guidance literature:: Multi-step reaction with 7 steps

1: 16.8 g / Et₃N / toluene / 12 h / 20 °C

2: 62 percent / chemical manganese dioxide; pyridine / benzene / 12 h / Heating

3: 91 percent / DIBAL / diethyl ether; hexane / 0.5 h / -78 °C

4: Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

5: 344 mg / LiBr / acetone; CH₂Cl₂ / 1 h / 20 °C

6: 94 percent / Pd(CH₃CN)2Cl₂ / 1-methyl-pyrrolidin-2-one / 0.17 h / 20 °C

7: 95 percent / CBr₄; Ph₃P / CH₂Cl₂ / 0 - 20 °C

With pyridine; manganese(IV) oxide; dichloro bis(acetonitrile) palladium(II); carbon tetrabromide; diisobutylaluminium hydride; triethylamine; triphenylphosphine; lithium bromide; In 1-methyl-pyrrolidin-2-one; diethyl ether; hexane; dichloromethane; acetone; toluene; benzene;
DOI:10.1016/S0040-4020(03)01020-2