benzyl (4-(2-(benzylamino)-1-(3-ethoxy-4-isopropoxyphenyl)-2-oxoethoxy)phenyl)(imino)-methylcarbamate trifluoroacetic acid

Base Information

Chemical Name:benzyl (4-(2-(benzylamino)-1-(3-ethoxy-4-isopropoxyphenyl)-2-oxoethoxy)phenyl)(imino)-methylcarbamate trifluoroacetic acid
CAS No.:1240804-13-0
Molecular Formula:C₂HF₃O₂*C₃₅H₃₇N₃O₆
Molecular Weight:709.719
Hs Code.:

Synonyms:benzyl (4-(2-(benzylamino)-1-(3-ethoxy-4-isopropoxyphenyl)-2-oxoethoxy)phenyl)(imino)-methylcarbamate trifluoroacetic acid

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Chemical Property of benzyl (4-(2-(benzylamino)-1-(3-ethoxy-4-isopropoxyphenyl)-2-oxoethoxy)phenyl)(imino)-methylcarbamate trifluoroacetic acid

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Technology Process of benzyl (4-(2-(benzylamino)-1-(3-ethoxy-4-isopropoxyphenyl)-2-oxoethoxy)phenyl)(imino)-methylcarbamate trifluoroacetic acid

There total 5 articles about benzyl (4-(2-(benzylamino)-1-(3-ethoxy-4-isopropoxyphenyl)-2-oxoethoxy)phenyl)(imino)-methylcarbamate trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 948992-49-2
2-(4-(N-(benzyloxycarbonyl)carbamimidoyl)phenoxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid

: 76-05-1
trifluoroacetic acid

: 1240804-13-0
benzyl (4-(2-(benzylamino)-1-(3-ethoxy-4-isopropoxyphenyl)-2-oxoethoxy)phenyl)(imino)-methylcarbamate trifluoroacetic acid

Guidance literature:: 2-(4-(N-(benzyloxycarbonyl)carbamimidoyl)phenoxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid; benzylamine; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

trifluoroacetic acid; In methanol; water;

Reference yield:

: 948992-44-7
methyl 2-(4-cyanophenoxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetate

: 1240804-13-0
benzyl (4-(2-(benzylamino)-1-(3-ethoxy-4-isopropoxyphenyl)-2-oxoethoxy)phenyl)(imino)-methylcarbamate trifluoroacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; triethylamine / dimethyl sulfoxide / 18.17 h / 20 - 60 °C

2: hydrogen; acetic anhydride / palladium 10% on activated carbon / 3 h / 20 °C

3: sodium hydrogencarbonate / dichloromethane; water / 1.5 h / 20 °C

4: methanol; lithium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

5: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With methanol; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydroxylamine hydrochloride; water; hydrogen; acetic anhydride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 745019-93-6
methyl 2-(3-ethoxy-4-isopropoxyphenyl)-2-hydroxyacetate

: 1240804-13-0
benzyl (4-(2-(benzylamino)-1-(3-ethoxy-4-isopropoxyphenyl)-2-oxoethoxy)phenyl)(imino)-methylcarbamate trifluoroacetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 18 h / 20 °C

2: hydroxylamine hydrochloride; triethylamine / dimethyl sulfoxide / 18.17 h / 20 - 60 °C

3: hydrogen; acetic anhydride / palladium 10% on activated carbon / 3 h / 20 °C

4: sodium hydrogencarbonate / dichloromethane; water / 1.5 h / 20 °C

5: methanol; lithium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

6: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With methanol; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydroxylamine hydrochloride; water; hydrogen; acetic anhydride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; 1: Mitsunobu reaction;