2-(4-(N-(benzyloxycarbonyl)carbamimidoyl)phenoxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid

Base Information

Chemical Name:2-(4-(N-(benzyloxycarbonyl)carbamimidoyl)phenoxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid
CAS No.:948992-49-2
Molecular Formula:C₂₈H₃₀N₂O₇
Molecular Weight:506.555
Hs Code.:

Synonyms:2-(4-(N-(benzyloxycarbonyl)carbamimidoyl)phenoxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid

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Chemical Property of 2-(4-(N-(benzyloxycarbonyl)carbamimidoyl)phenoxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid

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Technology Process of 2-(4-(N-(benzyloxycarbonyl)carbamimidoyl)phenoxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid

There total 5 articles about 2-(4-(N-(benzyloxycarbonyl)carbamimidoyl)phenoxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 948992-48-1
methyl 2-(4-(N-(benzyloxycarbonyl)carbamimidoyl)phenoxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetate

: 948992-49-2
2-(4-(N-(benzyloxycarbonyl)carbamimidoyl)phenoxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid

Guidance literature:: methyl 2-(4-(N-(benzyloxycarbonyl)carbamimidoyl)phenoxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetate; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 745019-93-6
methyl 2-(3-ethoxy-4-isopropoxyphenyl)-2-hydroxyacetate

: 948992-49-2
2-(4-(N-(benzyloxycarbonyl)carbamimidoyl)phenoxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 18 h / 20 °C

2: hydroxylamine hydrochloride; triethylamine / dimethyl sulfoxide / 18.17 h / 20 - 60 °C

3: hydrogen; acetic anhydride / palladium 10% on activated carbon / 3 h / 20 °C

4: sodium hydrogencarbonate / dichloromethane; water / 1.5 h / 20 °C

5: methanol; lithium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

With methanol; lithium hydroxide; hydroxylamine hydrochloride; water; hydrogen; acetic anhydride; sodium hydrogencarbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; 1: Mitsunobu reaction;

Reference yield:

: 948992-45-8
methyl 2-(4-(N-hydroxycarbamimidoyl)phenoxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetate

: 948992-49-2
2-(4-(N-(benzyloxycarbonyl)carbamimidoyl)phenoxy)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; acetic anhydride / palladium 10% on activated carbon / 3 h / 20 °C

2: sodium hydrogencarbonate / dichloromethane; water / 1.5 h / 20 °C

3: methanol; lithium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

With methanol; lithium hydroxide; water; hydrogen; acetic anhydride; sodium hydrogencarbonate; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; water;