1-methyl-2-[2-(4-cyanophenyl)-ethyl]-5-[N-(ethoxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole

Base Information

Chemical Name:1-methyl-2-[2-(4-cyanophenyl)-ethyl]-5-[N-(ethoxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole
CAS No.:256493-28-4
Molecular Formula:C₃₀H₂₇N₅O₄S
Molecular Weight:553.641
Hs Code.:

Synonyms:1-methyl-2-[2-(4-cyanophenyl)-ethyl]-5-[N-(ethoxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole

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Chemical Property of 1-methyl-2-[2-(4-cyanophenyl)-ethyl]-5-[N-(ethoxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole

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Technology Process of 1-methyl-2-[2-(4-cyanophenyl)-ethyl]-5-[N-(ethoxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole

There total 6 articles about 1-methyl-2-[2-(4-cyanophenyl)-ethyl]-5-[N-(ethoxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42287-94-5
(4-cyanophenyl)propionic acid

: 256493-28-4
1-methyl-2-[2-(4-cyanophenyl)-ethyl]-5-[N-(ethoxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: CDI / tetrahydrofuran / 50 °C

1.2: tetrahydrofuran / 50 °C

2.1: glacial acetic acid / Heating

3.1: H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 20 °C

4.1: pyridine / 20 °C

5.1: K₂CO₃ / acetone / Heating

With pyridine; hydrogen; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1021/jm0109513

Reference yield:

: 41939-61-1
N₁-methyl-4-nitrobenzene-1,2-diamine

: 256493-28-4
1-methyl-2-[2-(4-cyanophenyl)-ethyl]-5-[N-(ethoxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: CDI / tetrahydrofuran / 50 °C

1.2: tetrahydrofuran / 50 °C

2.1: glacial acetic acid / Heating

3.1: H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 20 °C

4.1: pyridine / 20 °C

5.1: K₂CO₃ / acetone / Heating

With pyridine; hydrogen; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1021/jm0109513

Reference yield:

: 256492-46-3
2-[2-(4-cyanophenyl)-ethyl]-1-methyl-5-nitro-benzimidazole

: 256493-28-4
1-methyl-2-[2-(4-cyanophenyl)-ethyl]-5-[N-(ethoxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 20 °C

2: pyridine / 20 °C

3: K₂CO₃ / acetone / Heating

With pyridine; hydrogen; potassium carbonate; 10percent Pd/C; In methanol; dichloromethane; acetone;
DOI:10.1021/jm0109513