41939-61-1

Basic information

• Product Name: N1-Methyl-4-nitro-o-phenyldiamin
• Synonyms: N1-Methyl-4-nitro-o-phenyldiamin;N~1~-methyl-4-nitro-1,2-benzenediamine;1-(Methylamino)-4-nitrobenzen-2-amine;N-Methyl-4-nitro-1,2-benzenediamine;N1-Methyl-4-nitrobenzene-1,2-diamine;1,2-benzenediamine, N~1~-methyl-4-nitro-;2-Methylamino-5-nitroaniline;N’-Methyl-4-nitrophenylene-1,2-diamine
• CAS NO: 41939-61-1
• Molecular Formula: C₇H₉N₃O₂
• Molecular Weight: 167.16526
• EINECS: 1308068-626-2
• Product Categories: API;Amines;Aromatics;amine | nitro-compound
• Mol File: 41939-61-1.mol
• Article Data: 20

Chemical Properties

• Melting Point: 174-176°
• Boiling Point: 366.8 °C at 760 mmHg
• Flash Point: 175.6 °C
• Appearance: Red powder
• Density: 1.359 g/cm³
• Vapor Pressure: 1.43E-05mmHg at 25°C
• Refractive Index: 1.682
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 4.23±0.10(Predicted)
• CAS DataBase Reference: N1-Methyl-4-nitro-o-phenyldiamin(CAS DataBase Reference)
• NIST Chemistry Reference: N1-Methyl-4-nitro-o-phenyldiamin(41939-61-1)
• EPA Substance Registry System: N1-Methyl-4-nitro-o-phenyldiamin(41939-61-1)

Safety Data

• RIDADR: UN 2811 6.1/PG III
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 41939-61-1(Hazardous Substances Data)

Usage

Chemical Properties

Red Powder

Uses

N’-Methyl-4-nitrophenylene-1,2-diamine (cas# 41939-61-1) is a compound useful in organic synthesis.

InChI:InChI=1/C7H9N3O2/c1-9-7-3-2-5(10(11)12)4-6(7)8/h2-4,9H,8H2,1H3

Upstream product

• 2044-88-4 N-methyl-2,4-dinitroaniline 
• 369-36-8 6-fluoro-3-nitroaniline 
• 593-51-1 methylamine hydrochloride 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 74-89-5 methylamine 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 1313-82-2 sodium sulfide 

Downstream Products

• 7466-45-7 6-nitro-2,3-diphenylquinoxaline 
• 1261079-64-4 1-methyl-5-nitro-1H-benzimidazol-2-amine hydrobromide salt 
• 3543-75-7 bendamustine hydrochloride 
• 82040-26-4 N-methyl-4-nitro-2-(4-(4-nitrophenyl)-1H-imidazol-1-yl)aniline 
• 82040-15-1 3-Methyl-6-nitro-1-[2-(4-nitro-phenyl)-2-oxo-ethyl]-3H-benzoimidazol-1-ium; bromide 
• 20443-39-4 2-(chloromethyl)-1-methyl-5-nitro-1H-benzo[d]imidazole 
• 27799-83-3 1-methyl-1H-benzo [d][1,2,3]triazole-5-amine 
• 106167-15-1 1-methyl-5-nitro-2-(4-nitrophenyl)-1H-benzo[d]imidazole 
• 70894-12-1 5-amino-2-(4-aminophenyl)-1-methylbenzimidazole 
• 53987-29-4 acetic acid-(2-methylamino-5-nitro-anilide) 
• 91332-91-1 N-(2-Methylamino-5-nitro-phenyl)-succinamic acid 
• 1033439-73-4 C₁₅H₁₃N₅*ClH 
• 1033439-72-3 C₁₅H₁₂N₄ 
• 444731-57-1 3-({4-[(1,2-dimethyl-1H-benzimidazol-5-yl)(methyl)amino]pyrimidin-2-yl}amino)benzenesulfonamide 

Relevant articles and documents

Flavin mimetics: Synthesis and photophysical properties

We report the synthesis of new isoalloxazines using a microwave-assisted approach to make N-substituted-2-nitroanilines followed by one-pot reduction and condensation via Hemmerich's method. The influence of substituents on positions 7, 8, and 10 of flavin core on the optical properties is investigated. The aliphatic functionalities on N10 give rise to quantum yields of 0.7, while aromatic side-chains quench fluorescence. Relaxed geometries (DFT) of chiral and achiral derivatives have been used for TD-DFT calculations, which yielded good agreement with the experimental UV and CD data.

Pyrimidineamines as angiogenesis modulators

Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

COMPOUNDS FOR USE IN INHIBITING HIV CAPSID ASSEMBLY

The present invention relates to a compound or a pharmaceutically acceptable salt or solvate thereof for use in inhibiting HIV capsid assembly, the compound comprising the core structure wherein E is CR7or S, and wherein f is 0 or 1, and wherein in case E is S, f is 0, and wherein the core structure is at least substituted in 2 and 4 position, and wherein the residue R6 and R7, are, independently of each other, selected from the group consisting of -H, -D, -alkyl, alkoxy, alkenyl, alkynyl, halides, -NO2, - OH, -NH2, -NHR4#, -CN, - S(O)R4#, -SO2R4#, -P(O)R4#R5#, -P(O)(OR4#)R5#, -P(O)(OR4#)(OR5#), -C(O)NR4#R5#, - C(O)SR4#, -C(O)R4#, -C(O)O-R4#, alkoxy and glycol chains; and wherein R6 may optionally form a cyclic residue, with a further substituent present 5 or 6 position, and wherein R4# and R5# are, independently of each other, selected from the group consisting of -H, -alkyl, -alkenyl, -heterocyclo alkyl, aryl and heteroaryl.