C₄₉H₅₈N₆O₁₂

Base Information

• Chemical Name: C₄₉H₅₈N₆O₁₂
• CAS No.: 115441-70-8
• Molecular Formula: C₄₉H₅₈N₆O₁₂
• Molecular Weight: 923.033
• Mol file: 115441-70-8.mol

Synonyms:C₄₉H₅₈N₆O₁₂

Chemical Property of C₄₉H₅₈N₆O₁₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₉H₅₈N₆O₁₂

There total 18 articles about C₄₉H₅₈N₆O₁₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

C50H60N6O12 (108969-73-9) → C49H58N6O12 (115441-70-8)

Guidance literature:

With sodium hydroxide; In methanol; acetonitrile; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.43.1325

Reference yield:

N-benzyloxycarbonyl-2,6-dichloro-N-methyltyrosine (108969-88-6) → C49H58N6O12 (115441-70-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 76 percent / N,N-dicyclohexylcarbodiimide / dioxane / 20 h / Ambient temperature

2: 5.2 percent / thallium(III) trinitrate / 18 h / 4 °C

3: 38 percent / 90percent aq. AcOH, Zn / 1 h / Ambient temperature

4: 78.4 percent / diethyl ether; methanol / 1 h / Ambient temperature

5: 71.4 percent / AcOK, H₂ / 5percent Pd/C / methanol / Ambient temperature

6: 63 percent / N,N-dicyclohexylcarbodimide / dioxane / 4 h / Ambient temperature

7: 24 percent / 1N aq. NaOH / methanol; acetonitrile / 0.5 h / Ambient temperature

With sodium hydroxide; hydrogen; potassium acetate; acetic acid; dicyclohexyl-carbodiimide; thallium(III) nitrate; zinc; palladium on activated charcoal; In 1,4-dioxane; methanol; diethyl ether; acetonitrile;

DOI:10.1248/cpb.43.1325

Reference yield:

2,6-dibromo-N-methyltyrosine methyl ester (108969-87-5) → C49H58N6O12 (115441-70-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 76 percent / N,N-dicyclohexylcarbodiimide / dioxane / 20 h / Ambient temperature

2: 5.2 percent / thallium(III) trinitrate / 18 h / 4 °C

3: 38 percent / 90percent aq. AcOH, Zn / 1 h / Ambient temperature

4: 78.4 percent / diethyl ether; methanol / 1 h / Ambient temperature

5: 71.4 percent / AcOK, H₂ / 5percent Pd/C / methanol / Ambient temperature

6: 63 percent / N,N-dicyclohexylcarbodimide / dioxane / 4 h / Ambient temperature

7: 24 percent / 1N aq. NaOH / methanol; acetonitrile / 0.5 h / Ambient temperature

With sodium hydroxide; hydrogen; potassium acetate; acetic acid; dicyclohexyl-carbodiimide; thallium(III) nitrate; zinc; palladium on activated charcoal; In 1,4-dioxane; methanol; diethyl ether; acetonitrile;

DOI:10.1248/cpb.43.1325

upstream raw materials:

C₅₀H₆₀N₆O₁₂

N-methyl-L-tyrosine

L,L-N,N-dimethylcycloisodityrosine methyl ester

N-Cbz-D-alanyl-L-alanyl-N,O-dimethyl-L-tyrosyl-L-alanine

Downstream raw materials:

C₄₁H₅₂N₆O₁₀

deoxybouvadin

RA-VII

C₃₉H₄₆N₆O₉