tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-(tert-butylsulfonylmethyl)cyclohexylcarbamate

Base Information

Chemical Name:tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-(tert-butylsulfonylmethyl)cyclohexylcarbamate
CAS No.:848002-02-8
Molecular Formula:C₂₈H₄₃N₃O₇S
Molecular Weight:565.731
Hs Code.:

Synonyms:tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-(tert-butylsulfonylmethyl)cyclohexylcarbamate

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Chemical Property of tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-(tert-butylsulfonylmethyl)cyclohexylcarbamate

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Technology Process of tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-(tert-butylsulfonylmethyl)cyclohexylcarbamate

There total 7 articles about tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-(tert-butylsulfonylmethyl)cyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₅₀N₃O₅S₂⁽¹⁺⁾*I^(1-)

: 848002-02-8
tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-(tert-butylsulfonylmethyl)cyclohexylcarbamate

Guidance literature:: With caesium carbonate; In DMF (N,N-dimethyl-formamide); for 12h;

Reference yield:

: 848001-99-0
tert-butyl (1R,3R,4S)-4-benzyloxycarbonylamino-3-(tert-butylthiomethyl)cyclohexylcarbamate

: 848002-02-8
tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-(tert-butylsulfonylmethyl)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: ozone / isopropyl alcohol; water

2: hydrogen; palladium on activated charcoal / methanol

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide

4: methyl iodide; caesium carbonate / N,N-dimethyl-formamide

With 4-methyl-morpholine; palladium on activated charcoal; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; ozone; methyl iodide; In methanol; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2014.02.013

Reference yield:

: 746670-92-8
benzyl (1S,2R,4R)-4-(tert-butoxycarbonylamino)-2-(hydroxymethyl)cyclohexylcarbamate

: 848002-02-8
tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-(tert-butylsulfonylmethyl)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 0 °C

2: N,N-dimethyl-formamide

3: ozone / isopropyl alcohol; water

4: hydrogen; palladium on activated charcoal / methanol

5: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide

6: methyl iodide; caesium carbonate / N,N-dimethyl-formamide

With 4-methyl-morpholine; palladium on activated charcoal; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; ozone; triethylamine; methyl iodide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2014.02.013