tert-butyl (1R,3R,4S)-4-benzyloxycarbonylamino-3-(tert-butylthiomethyl)cyclohexylcarbamate

Base Information

Chemical Name:tert-butyl (1R,3R,4S)-4-benzyloxycarbonylamino-3-(tert-butylthiomethyl)cyclohexylcarbamate
CAS No.:848001-99-0
Molecular Formula:C₂₄H₃₈N₂O₄S
Molecular Weight:450.643
Hs Code.:

Synonyms:tert-butyl (1R,3R,4S)-4-benzyloxycarbonylamino-3-(tert-butylthiomethyl)cyclohexylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (1R,3R,4S)-4-benzyloxycarbonylamino-3-(tert-butylthiomethyl)cyclohexylcarbamate

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Technology Process of tert-butyl (1R,3R,4S)-4-benzyloxycarbonylamino-3-(tert-butylthiomethyl)cyclohexylcarbamate

There total 3 articles about tert-butyl (1R,3R,4S)-4-benzyloxycarbonylamino-3-(tert-butylthiomethyl)cyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 847956-83-6
(1R,3R,4S)-(4-benzyloxycarbonylamino-3-methoxymethylcyclohexyl)carbamic acid tert-butyl ester

: 29364-29-2
sodium tert-butyl thiolate

: 848001-99-0
tert-butyl (1R,3R,4S)-4-benzyloxycarbonylamino-3-(tert-butylthiomethyl)cyclohexylcarbamate

Guidance literature:: In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.02.013

Reference yield:

: ((1R,2S,5R)-2-benzyloxycarbonylamino-5-(tert-butoxycarbonyl)cyclohexyl)methyl methanesulfonate

: 29364-29-2
sodium tert-butyl thiolate

: 848001-99-0
tert-butyl (1R,3R,4S)-4-benzyloxycarbonylamino-3-(tert-butylthiomethyl)cyclohexylcarbamate

Guidance literature:: In N,N,N,N,N,N-hexamethylphosphoric triamide; DMF (N,N-dimethyl-formamide); at 0 - 20 ℃;

Reference yield:

: 746670-92-8
benzyl (1S,2R,4R)-4-(tert-butoxycarbonylamino)-2-(hydroxymethyl)cyclohexylcarbamate

: 848001-99-0
tert-butyl (1R,3R,4S)-4-benzyloxycarbonylamino-3-(tert-butylthiomethyl)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 °C

2: N,N-dimethyl-formamide

With triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.02.013