N-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]-N'-((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)urea

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Chemical Name:N-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]-N'-((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)urea
CAS No.:852660-52-7
Molecular Formula:C₂₈H₃₆FN₇O
Molecular Weight:505.639
Hs Code.:

Synonyms:N-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]-N'-((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)urea

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Chemical Property of N-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]-N'-((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)urea

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Technology Process of N-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]-N'-((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)urea

There total 15 articles about N-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]-N'-((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 852660-56-1
N-{[(1S,2R)-2-aminocyclohexyl]methyl}-(2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-amine

: 675122-49-3
phenyl 3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenylcarbamate

: 852660-52-7
N-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]-N'-((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)urea

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 18h;

Reference yield:

: 6307-83-1
3-bromo-5-nitro-benzoic acid

: 852660-52-7
N-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]-N'-((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2: tetrahydrofuran / 16 h / 0 - 20 °C

3: sodium azide; trifluoromethylsulfonic anhydride / acetonitrile / 4 h / 0 - 25 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 2 h / 25 °C / Heating / reflux

5: hydrogen / palladium dihydroxide / methanol / 4 h / 2585.81 Torr

6: 2,6-dimethylpyridine / tetrahydrofuran / 1 h / 0 - 25 °C

7: triethylamine / acetonitrile / 18 h / 20 °C

With 2,6-dimethylpyridine; sodium azide; oxalyl dichloride; trifluoromethylsulfonic anhydride; hydrogen; triethylamine; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 275815-60-6
(1R,2R)-2-(benzyloxycarbonylamino)cyclohexanecarboxaldehyde

: 852660-52-7
N-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]-N'-((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 1,2-dichloro-ethane

1.2: 3.5 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 3.5 h / 3604.44 Torr

3.1: triethylamine / acetonitrile / 18 h / 20 °C

With hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; 1,2-dichloro-ethane; acetonitrile;