N-(4-aminobutyl)-N-(3-hydroxypropyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(4-aminobutyl)-N-(3-hydroxypropyl)-4-methylbenzenesulfonamide
• CAS No.: 708197-76-6
• Molecular Formula: C₁₄H₂₄N₂O₃S
• Molecular Weight: 300.422
• Mol file: 708197-76-6.mol

Synonyms:N-(4-aminobutyl)-N-(3-hydroxypropyl)-4-methylbenzenesulfonamide

Chemical Property of N-(4-aminobutyl)-N-(3-hydroxypropyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-aminobutyl)-N-(3-hydroxypropyl)-4-methylbenzenesulfonamide

There total 2 articles about N-(4-aminobutyl)-N-(3-hydroxypropyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-[(3-cyanopropyl)-p-toluenesulfonylamino]propionic acid methyl ester (708197-75-5) → N-(4-aminobutyl)-N-(3-hydroxypropyl)-4-methylbenzenesulfonamide (708197-76-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jo049724+

Reference yield:

N-(3-Cyano-propyl)-4-methyl-benzenesulfonamide (13380-03-5) → N-(4-aminobutyl)-N-(3-hydroxypropyl)-4-methylbenzenesulfonamide (708197-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / K₂CO₃ / acetonitrile / 4 h / 20 °C

2: 70 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jo049724+

Reference yield:

N-(4-aminobutyl)-N-(3-hydroxypropyl)-4-methylbenzenesulfonamide (708197-76-6) → N-(4-benzylaminobutyl)-N-(3-hydroxypropyl)-4-methylbenzenesulfonamide (708197-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: MgSO₄ / CHCl₃ / 18 h / Heating

2: 200 mg / NaBH₄ / methanol / 1 h / 20 °C

With sodium tetrahydroborate; magnesium sulfate; In methanol; chloroform;

DOI:10.1021/jo049724+

upstream raw materials:

3-[(3-cyanopropyl)-p-toluenesulfonylamino]propionic acid methyl ester

N-(3-Cyano-propyl)-4-methyl-benzenesulfonamide

Downstream raw materials:

2-[1-(1-benzyloxyhexyl)-3-oxo-1,5,6,8a-tetrahydrooxazolo[3,4-a]pyridin-5-yl]-N-{4-[(3-hydroxypropyl)-(toluene-4-sulfonyl)amino]butyl}acetamide

N-(4-benzylaminobutyl)-N-(3-hydroxypropyl)-4-methylbenzenesulfonamide

(1R,1'S,5R,9R)-N-benzyl-N-{4-[(3-hydroxypropyl)(toluene-4-sulfonyl)amino]butyl}-2-[3-oxo-1-((1'-phenylmethoxy)hexyl)-1,5,6,8a-tetrahydrooxazolo[3,4-a]pyridin-5-yl]acetamide