3-[(3-cyanopropyl)-p-toluenesulfonylamino]propionic acid methyl ester

Base Information

• Chemical Name: 3-[(3-cyanopropyl)-p-toluenesulfonylamino]propionic acid methyl ester
• CAS No.: 708197-75-5
• Molecular Formula: C₁₅H₂₀N₂O₄S
• Molecular Weight: 324.401
• Mol file: 708197-75-5.mol

Synonyms:3-[(3-cyanopropyl)-p-toluenesulfonylamino]propionic acid methyl ester

Chemical Property of 3-[(3-cyanopropyl)-p-toluenesulfonylamino]propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-[(3-cyanopropyl)-p-toluenesulfonylamino]propionic acid methyl ester

There total 1 articles about 3-[(3-cyanopropyl)-p-toluenesulfonylamino]propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(3-Cyano-propyl)-4-methyl-benzenesulfonamide (13380-03-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 3-[(3-cyanopropyl)-p-toluenesulfonylamino]propionic acid methyl ester (708197-75-5)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1021/jo049724+

Reference yield: 70.0%

3-[(3-cyanopropyl)-p-toluenesulfonylamino]propionic acid methyl ester (708197-75-5) → N-(4-aminobutyl)-N-(3-hydroxypropyl)-4-methylbenzenesulfonamide (708197-76-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jo049724+

Reference yield:

3-[(3-cyanopropyl)-p-toluenesulfonylamino]propionic acid methyl ester (708197-75-5) → N-(4-benzylimino-butyl)-N-(3-hydroxy-propyl)-4-methyl-benzenesulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

2: MgSO₄ / CHCl₃ / 18 h / Heating

With lithium aluminium tetrahydride; magnesium sulfate; In tetrahydrofuran; chloroform;

DOI:10.1021/jo049724+

upstream raw materials:

N-(3-Cyano-propyl)-4-methyl-benzenesulfonamide

acrylic acid methyl ester

Downstream raw materials:

N-(4-aminobutyl)-N-(3-hydroxypropyl)-4-methylbenzenesulfonamide

N-(4-benzylaminobutyl)-N-(3-hydroxypropyl)-4-methylbenzenesulfonamide

2-[1-(1-benzyloxyhexyl)-3-oxo-1,5,6,8a-tetrahydrooxazolo[3,4-a]pyridin-5-yl]-N-{4-[(3-hydroxypropyl)-(toluene-4-sulfonyl)amino]butyl}acetamide

(1R,1'S,5R,9R)-N-benzyl-N-{4-[(3-hydroxypropyl)(toluene-4-sulfonyl)amino]butyl}-2-[3-oxo-1-((1'-phenylmethoxy)hexyl)-1,5,6,8a-tetrahydrooxazolo[3,4-a]pyridin-5-yl]acetamide