(+)-(2R,4R,6R,8R)tert-butyl-diphenyl-(2,4,6,8-tetramethyl-octacosyloxy)-silane

Base Information

Chemical Name:(+)-(2R,4R,6R,8R)tert-butyl-diphenyl-(2,4,6,8-tetramethyl-octacosyloxy)-silane
CAS No.:930121-01-0
Molecular Formula:C₄₈H₈₄OSi
Molecular Weight:705.28
Hs Code.:

Synonyms:(+)-(2R,4R,6R,8R)tert-butyl-diphenyl-(2,4,6,8-tetramethyl-octacosyloxy)-silane

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Chemical Property of (+)-(2R,4R,6R,8R)tert-butyl-diphenyl-(2,4,6,8-tetramethyl-octacosyloxy)-silane

Chemical Property:

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Technology Process of (+)-(2R,4R,6R,8R)tert-butyl-diphenyl-(2,4,6,8-tetramethyl-octacosyloxy)-silane

There total 15 articles about (+)-(2R,4R,6R,8R)tert-butyl-diphenyl-(2,4,6,8-tetramethyl-octacosyloxy)-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 930121-00-9
(+)-(3S,5S,7R,9R)-toluene-4-sulfonic acid 10-(tert-butyl-diphenyl-silanyloxy)-3,5,7,9-tetramethyl-decyl ester

: 112-89-0
1-Bromooctadecane

: 930121-01-0
(+)-(2R,4R,6R,8R)tert-butyl-diphenyl-(2,4,6,8-tetramethyl-octacosyloxy)-silane

Guidance literature:: 1-Bromooctadecane; With magnesium; In tetrahydrofuran; at 45 ℃; for 1h;

(+)-(3S,5S,7R,9R)-toluene-4-sulfonic acid 10-(tert-butyl-diphenyl-silanyloxy)-3,5,7,9-tetramethyl-decyl ester; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1039/b612593j

Reference yield:

: 917590-73-9
(E)-4-(tert-butyl-diphenyl-silanyloxy)-but-2-enethioic acid S-ethyl ester

: 930121-01-0
(+)-(2R,4R,6R,8R)tert-butyl-diphenyl-(2,4,6,8-tetramethyl-octacosyloxy)-silane

Guidance literature:: Multi-step reaction with 13 steps

1.1: (S,R_Fe)-Josiphos*CuBr complex / various solvent(s); diethyl ether / 0.33 h / -75 °C

1.2: 95 percent / various solvent(s); diethyl ether / 17 h / -75 °C

2.1: Et₃SiH / Pd-C / CH₂Cl₂ / 20 °C

3.1: 1.491 g / CH₂Cl₂ / 24 h / Heating

4.1: (S,R_Fe)-Josiphos*CuBr complex / various solvent(s); diethyl ether / 0.33 h / -75 °C

4.2: 90 percent / various solvent(s); diethyl ether / 17 h / -75 °C

5.1: Et₃SiH / Pd-C / CH₂Cl₂ / 20 °C

6.1: 214 mg / CH₂Cl₂ / 24 h / Heating

7.1: (S,R_Fe)-Josiphos*CuBr complex / various solvent(s); diethyl ether / 0.33 h / -75 °C

7.2: 85 percent / various solvent(s); diethyl ether / 17 h / -75 °C

8.1: Et₃SiH / Pd-C / CH₂Cl₂ / 20 °C

9.1: 1.102 g / CH₂Cl₂ / 24 h / Heating

10.1: (S,R_Fe)-Josiphos*CuBr complex / various solvent(s); diethyl ether / 0.17 h / -75 °C

10.2: 88 percent / various solvent(s); diethyl ether / 17 h / -75 °C

11.1: 95 percent / DIBAL-H / tetrahydrofuran; CH₂Cl₂ / -20 °C

12.1: 95 percent / pyridine / CH₂Cl₂ / 24 h / 20 °C

13.1: magnesium / tetrahydrofuran / 1 h / 45 °C

13.2: 80 percent / CuBr*SMe₂ / tetrahydrofuran / 24 h / 20 °C

With pyridine; triethylsilane; diisobutylaluminium hydride; magnesium; palladium on activated charcoal; (S,R_Fe)-Josiphos*CuBr; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1039/b612593j

Reference yield:

: 6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexanal

: 930121-01-0
(+)-(2R,4R,6R,8R)tert-butyl-diphenyl-(2,4,6,8-tetramethyl-octacosyloxy)-silane

Guidance literature:: Multi-step reaction with 8 steps

1.1: 214 mg / CH₂Cl₂ / 24 h / Heating

2.1: (S,R_Fe)-Josiphos*CuBr complex / various solvent(s); diethyl ether / 0.33 h / -75 °C

2.2: 85 percent / various solvent(s); diethyl ether / 17 h / -75 °C

3.1: Et₃SiH / Pd-C / CH₂Cl₂ / 20 °C

4.1: 1.102 g / CH₂Cl₂ / 24 h / Heating

5.1: (S,R_Fe)-Josiphos*CuBr complex / various solvent(s); diethyl ether / 0.17 h / -75 °C

5.2: 88 percent / various solvent(s); diethyl ether / 17 h / -75 °C

6.1: 95 percent / DIBAL-H / tetrahydrofuran; CH₂Cl₂ / -20 °C

7.1: 95 percent / pyridine / CH₂Cl₂ / 24 h / 20 °C

8.1: magnesium / tetrahydrofuran / 1 h / 45 °C

8.2: 80 percent / CuBr*SMe₂ / tetrahydrofuran / 24 h / 20 °C

With pyridine; triethylsilane; diisobutylaluminium hydride; magnesium; palladium on activated charcoal; (S,R_Fe)-Josiphos*CuBr; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1039/b612593j