Technology Process of Butanethioic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-,
S-ethyl ester, (3R)-
There total 4 articles about Butanethioic acid, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-,
S-ethyl ester, (3R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methylmagnesium bromide;
(S,RFe)-Josiphos*CuBr;
In
diethyl ether;
at -75 ℃;
for 0.333333h;
(E)-4-(tert-butyl-diphenyl-silanyloxy)-but-2-enethioic acid S-ethyl ester;
In
diethyl ether;
at -75 ℃;
for 17h;
DOI:10.1039/b612593j
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 79 percent / imidazole / tetrahydrofuran / 24 h / 20 °C
2.1: iodoxybenzoic acid / ethyl acetate / 24 h / Heating
3.1: 80 percent / CH2Cl2 / 24 h / Heating
4.1: (S,Rp)-Josiphos CuBr complex / diethyl ether; various solvent(s) / cooling
4.2: diethyl ether; various solvent(s) / cooling
With
1H-imidazole; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
(S,Rp)-Josiphos CuBr complex;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;
3.1: Wittig reaction;
DOI:10.1021/ol071078o
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: iodoxybenzoic acid / ethyl acetate / 24 h / Heating
2.1: 80 percent / CH2Cl2 / 24 h / Heating
3.1: (S,Rp)-Josiphos CuBr complex / diethyl ether; various solvent(s) / cooling
3.2: diethyl ether; various solvent(s) / cooling
With
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
(S,Rp)-Josiphos CuBr complex;
In
diethyl ether; dichloromethane; ethyl acetate;
2.1: Wittig reaction;
DOI:10.1021/ol071078o
