1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(6-(3,4-dimethoxyphenylethylamino)-9H-purin-2-yl)-D-glucitol

Base Information

Chemical Name:1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(6-(3,4-dimethoxyphenylethylamino)-9H-purin-2-yl)-D-glucitol
CAS No.:1292814-83-5
Molecular Formula:C₃₅H₄₀N₆O₆
Molecular Weight:640.739
Hs Code.:

Synonyms:1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(6-(3,4-dimethoxyphenylethylamino)-9H-purin-2-yl)-D-glucitol

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Chemical Property of 1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(6-(3,4-dimethoxyphenylethylamino)-9H-purin-2-yl)-D-glucitol

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Technology Process of 1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(6-(3,4-dimethoxyphenylethylamino)-9H-purin-2-yl)-D-glucitol

There total 8 articles about 1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(6-(3,4-dimethoxyphenylethylamino)-9H-purin-2-yl)-D-glucitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 176756-87-9
1-amino-2,5-anhydro-1-deoxy-3,4-di-O-benzyl-D-glucitol

: 1292814-80-2
2-iodo-6-(3,4-dimethoxyphenethylamino)-9H-purine

: 1292814-83-5
1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(6-(3,4-dimethoxyphenylethylamino)-9H-purin-2-yl)-D-glucitol

Guidance literature:: With sodium tetrafluoroborate; In 1,4-dioxane; at 130 ℃; for 2h; Microwave irradiation;
DOI:10.1016/j.ejmech.2011.01.048

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 1292814-83-5
1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(6-(3,4-dimethoxyphenylethylamino)-9H-purin-2-yl)-D-glucitol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / butan-1-ol / 6 h / 80 °C

2: sodium tetrafluoroborate / 1,4-dioxane / 2 h / 130 °C / Microwave irradiation

With sodium tetrafluoroborate; triethylamine; In 1,4-dioxane; butan-1-ol;
DOI:10.1016/j.ejmech.2011.01.048

Reference yield:

: 10310-21-1
2-Amino-6-chloropurin

: 1292814-83-5
1-amino-2,5-anhydro-3,4-di-O-benzyl-1-deoxy-N-(6-(3,4-dimethoxyphenylethylamino)-9H-purin-2-yl)-D-glucitol

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere

2: copper(l) iodide; diiodomethane; iodine; isopentyl nitrite / acetonitrile / 2 h / Reflux; Inert atmosphere

3: water; sodium hydroxide / isopropyl alcohol / 72 h / 20 °C

4: triethylamine / butan-1-ol / 6 h / 80 °C

5: sodium tetrafluoroborate / 1,4-dioxane / 2 h / 130 °C / Microwave irradiation

With copper(l) iodide; sodium tetrafluoroborate; diiodomethane; water; iodine; caesium carbonate; triethylamine; sodium hydroxide; isopentyl nitrite; In 1,4-dioxane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; butan-1-ol;
DOI:10.1016/j.ejmech.2011.01.048