(4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate

Base Information

Chemical Name:(4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
CAS No.:1187595-90-9
Molecular Formula:C₂₂H₂₇N₇O₄S
Molecular Weight:485.567
Hs Code.:
Mol file:1187595-90-9.mol

Synonyms:(4-{1-[3-(cyanomethyl)-1-(ethylsulphonyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate

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Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate

There total 11 articles about (4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

: (4-{1-[3-(cyanomethyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate

: 1187595-90-9
(4-{1-[3-(cyanomethyl)-1-(ethylsulphonyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; Ethanesulfonyl chloride; In ethyl acetate; at 0 - 20 ℃; for 1.5h; Solvent; Temperature;

Reference yield: 61.6%

: 3724-43-4,149409-22-3
Vilsmeier reagent

: 2-(1-(ethylsulfonyl)-3-hydrazinoazetidin-3-yl)acetonitrile

: (4-(1,3-dioxolane-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-7-yl)methyl pivalate

: 1187595-90-9
(4-{1-[3-(cyanomethyl)-1-(ethylsulphonyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate

Guidance literature:: Vilsmeier reagent; (4-(1,3-dioxolane-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-7-yl)methyl pivalate; In 2-methyltetrahydrofuran; at 50 - 65 ℃; for 1.5h; Inert atmosphere;

2-(1-(ethylsulfonyl)-3-hydrazinoazetidin-3-yl)acetonitrile; In 2-methyltetrahydrofuran; at 60 - 65 ℃; for 3h; Inert atmosphere;

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1187595-90-9
(4-{1-[3-(cyanomethyl)-1-(ethylsulphonyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 3 h / 72 °C / Inert atmosphere

3: acetyl chloride / methanol / 6 h / 5 - 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 3 h / 5 - 10 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; acetyl chloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;