(S)-2-phenyl-2-piperidin-1-yl-propionic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester

Base Information

Chemical Name:(S)-2-phenyl-2-piperidin-1-yl-propionic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester
CAS No.:1034917-42-4
Molecular Formula:C₂₁H₃₀N₂O₂
Molecular Weight:342.481
Hs Code.:

Synonyms:(S)-2-phenyl-2-piperidin-1-yl-propionic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-phenyl-2-piperidin-1-yl-propionic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester

Chemical Property:

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Technology Process of (S)-2-phenyl-2-piperidin-1-yl-propionic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester

There total 4 articles about (S)-2-phenyl-2-piperidin-1-yl-propionic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1034912-54-3
(S)-methyl 2-phenyl-2-(piperdin-1-yl)propanoate

: 25333-42-0
(R)-quinuclidin-3-ol

: 1034917-42-4
(S)-2-phenyl-2-piperidin-1-yl-propionic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester

Guidance literature:: With sodium hydride; In toluene; mineral oil; at 120 ℃; for 8h; Inert atmosphere;

Reference yield:

: 31508-44-8
2-phenylpropionic acid methyl ester

: 1034917-42-4
(S)-2-phenyl-2-piperidin-1-yl-propionic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); Methyl formate / Irradiation; Reflux

2: acetonitrile / 20 °C

3: sodium hydride / toluene; mineral oil / Reflux

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); Methyl formate; sodium hydride; In toluene; acetonitrile; mineral oil;
DOI:10.1016/j.bmcl.2011.10.002

Reference yield:

: 84892-13-7,148600-13-9
methyl 2-bromo-2-phenylpropanoate

: 1034917-42-4
(S)-2-phenyl-2-piperidin-1-yl-propionic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 20 °C

2: sodium hydride / toluene; mineral oil / Reflux

With sodium hydride; In toluene; acetonitrile; mineral oil;
DOI:10.1016/j.bmcl.2011.10.002