31508-44-8

Basic information

• Product Name: R,S-2-Phenyl-propionicacidmethylester
• Synonyms: R,S-2-Phenyl-propionicacidmethylester;methyl 2-phenylpropionate;2-PHENYLPROPANOIC ACID METHYL ESTER;(2S)-2-Phenylpropionic acid methyl ester;(S)-2-Phenylpropionic acid methyl ester;[S,(+)]-2-Phenylpropionic acid methyl ester;(2R)-2-Phenylpropionic acid methyl ester;(R)-2-Phenylpropionic acid methyl ester
• CAS NO: 31508-44-8
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.20108
• EINECS: 250-667-9
• Mol File: 31508-44-8.mol
• Article Data: 242

Chemical Properties

• Boiling Point: 212.3°Cat760mmHg
• Flash Point: 89.3°C
• Appearance: /
• Density: 1.029g/cm³
• Vapor Pressure: 0.174mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: R,S-2-Phenyl-propionicacidmethylester(CAS DataBase Reference)
• NIST Chemistry Reference: R,S-2-Phenyl-propionicacidmethylester(31508-44-8)
• EPA Substance Registry System: R,S-2-Phenyl-propionicacidmethylester(31508-44-8)

Safety Data

• Hazardous Substances Data: 31508-44-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 43, p. 2170, 1978 DOI: 10.1021/jo00405a019Synthesis, p. 880, 1979 DOI: 10.1055/s-1979-28857Tetrahedron Letters, 30, p. 371, 1989 DOI: 10.1016/S0040-4039(00)95205-5

InChI:InChI=1/C10H12O2/c1-8(10(11)12-2)9-6-4-3-5-7-9/h3-8H,1-2H3

Upstream product

• 13049-41-7 1,1-dimethoxy-2-phenylethene 
• 100058-89-7 (+/-)-methyl 2-methoxy-2-phenylpropionate 
• 20047-41-0 (2R)-methyl 2-bromopropionate 
• 1865-29-8 2-phenyl-acrylic acid methyl ester 
• 101-41-7 benzeneacetic acid methyl ester 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 2510-99-8 ethyl 2-phenylpropanoate 
• 186581-53-3 diazomethane 
• 492-37-5 hydratropic acid 
• 100-42-5 styrene 
• 201230-82-2 carbon monoxide 
• 673-32-5 1-Phenylprop-1-yne 
• 14088-57-4 2-diazo-1-phenyl-1-propanone 

Downstream Products

• 116342-25-7 (+/-)-N-benzyl-2-phenylpropanamide 
• 28645-07-0 (S)-methyl 2-phenylpropanoate 
• 2328-26-9 methyl (R)-2-phenylpropanoate 
• 124658-21-5 Methyl α-fluoro-α-methylbenzeneacetate 
• 117606-78-7 (S)-2-Methyl-3-oxo-2-phenyl-hexanoic acid methyl ester 
• 492-37-5 hydratropic acid 
• 7782-24-3 (S)-2-Phenylpropionic acid 
• 7782-26-5 (R)-2-Phenylpropionic acid 
• 4842-49-3 (R)-2-(4-methoxyphenyl)propionic acid 
• 13448-81-2 (S)-methyl atrolactate 
• 13448-80-1 methyl R-(-)-atrolactate 
• 20731-95-7 methyl 2-hydroxy-2-phenylpropanoate 
• 84892-13-7 methyl 2-bromo-2-phenylpropanoate 
• 115420-22-9 2-phenyl-2-<4'-(methylcarbomethoxymethyl)phenyl>propanoate 

Relevant articles and documents

Continuous in situ electrogenaration of a 2-pyrrolidone anion in a microreactor: application to highly efficient monoalkylation of methyl phenylacetate

We have successfully demonstrated effective generation of an electrogenerated base (EGB) such as the 2-pyrrolidone anion and its rapid use for the following alkylation reaction in a flow microreactor system without the need for severe reaction conditions. The key feature of the method is effective and selective preparation of monoalkylated products.

Green Esterification of Carboxylic Acids Promoted by tert-Butyl Nitrite

In this work, the green esterification of carboxylic acids promoted by tert-butyl nitrite has been well developed. This transformation is compatible with a broad range of substrates and exhibits excellent functional group tolerance. Various drugs and substituted amino acids are applicable to this reaction under near neutral conditions, with good to excellent yields.

Enantioselective α-Arylation of Ketones via a Novel Cu(I)-Bis(phosphine) Dioxide Catalytic System

A novel catalytic system based on copper(I) and chiral bis(phosphine) dioxides is described. This allows the arylation of silyl enol ethers to access enolizable α-arylated ketones in good yields and enantiomeric excess up to 95%. Noncyclic ketones are amenable substrates with this method, which complements other approaches based on palladium catalysis. Optimization of the ligand structure is accomplished via rational design driven by correlation analysis. Preliminary mechanistic hypotheses are also evaluated in order to identify the role of chiral bis(phosphine) dioxides.