ethyl 2-(4-fluorophenyl)-6-(methyl(1-phenylethyl)amino)-5-phenyl-1-benzofuran-3-carboxylate

Base Information

Chemical Name:ethyl 2-(4-fluorophenyl)-6-(methyl(1-phenylethyl)amino)-5-phenyl-1-benzofuran-3-carboxylate
CAS No.:1333224-93-3
Molecular Formula:C₃₂H₂₈FNO₃
Molecular Weight:493.578
Hs Code.:

Synonyms:ethyl 2-(4-fluorophenyl)-6-(methyl(1-phenylethyl)amino)-5-phenyl-1-benzofuran-3-carboxylate

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Chemical Property of ethyl 2-(4-fluorophenyl)-6-(methyl(1-phenylethyl)amino)-5-phenyl-1-benzofuran-3-carboxylate

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Technology Process of ethyl 2-(4-fluorophenyl)-6-(methyl(1-phenylethyl)amino)-5-phenyl-1-benzofuran-3-carboxylate

There total 5 articles about ethyl 2-(4-fluorophenyl)-6-(methyl(1-phenylethyl)amino)-5-phenyl-1-benzofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.7%

: 1333224-91-1
ethyl 2-(4-fluorophenyl)-5-phenyl-6-((1-phenylethyl)amino)-1-benzofuran-3-carboxylate

: 74-88-4
methyl iodide

: 1333224-93-3
ethyl 2-(4-fluorophenyl)-6-(methyl(1-phenylethyl)amino)-5-phenyl-1-benzofuran-3-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 16h;

Reference yield:

: 691857-51-9
ethyl 2-(4-fluorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

: 1333224-93-3
ethyl 2-(4-fluorophenyl)-6-(methyl(1-phenylethyl)amino)-5-phenyl-1-benzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate tribasic trihydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere

2: water; iron; ammonium chloride / tetrahydrofuran; methanol / 4 h / Reflux

3: caesium carbonate / N,N-dimethyl-formamide / 4 h / 140 °C

4: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

With potassium phosphate tribasic trihydrate; water; iron; potassium carbonate; ammonium chloride; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 98-80-6
phenylboronic acid

: 1333224-93-3
ethyl 2-(4-fluorophenyl)-6-(methyl(1-phenylethyl)amino)-5-phenyl-1-benzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate tribasic trihydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere

2: water; iron; ammonium chloride / tetrahydrofuran; methanol / 4 h / Reflux

3: caesium carbonate / N,N-dimethyl-formamide / 4 h / 140 °C

4: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

With potassium phosphate tribasic trihydrate; water; iron; potassium carbonate; ammonium chloride; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;