N-(3,4-dimethylisoxazol-5-yl)-2-(3-methoxyphenyl)-7-azaspiro[3.5]nonane-7-carboxamide

Base Information

Chemical Name:N-(3,4-dimethylisoxazol-5-yl)-2-(3-methoxyphenyl)-7-azaspiro[3.5]nonane-7-carboxamide
CAS No.:1225275-49-9
Molecular Formula:C₂₁H₂₇N₃O₃
Molecular Weight:369.464
Hs Code.:

Synonyms:N-(3,4-dimethylisoxazol-5-yl)-2-(3-methoxyphenyl)-7-azaspiro[3.5]nonane-7-carboxamide

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Chemical Property of N-(3,4-dimethylisoxazol-5-yl)-2-(3-methoxyphenyl)-7-azaspiro[3.5]nonane-7-carboxamide

Chemical Property:

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Technology Process of N-(3,4-dimethylisoxazol-5-yl)-2-(3-methoxyphenyl)-7-azaspiro[3.5]nonane-7-carboxamide

There total 5 articles about N-(3,4-dimethylisoxazol-5-yl)-2-(3-methoxyphenyl)-7-azaspiro[3.5]nonane-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81479-66-5
phenyl (3,4-dimethylisoxazol-5-yl)carbamate

: 1225276-72-1
C₁₅H₂₁NO*ClH

: 1225275-49-9
N-(3,4-dimethylisoxazol-5-yl)-2-(3-methoxyphenyl)-7-azaspiro[3.5]nonane-7-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 2h;

Reference yield:

: 240401-28-9
2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

: 1225275-49-9
N-(3,4-dimethylisoxazol-5-yl)-2-(3-methoxyphenyl)-7-azaspiro[3.5]nonane-7-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran

2: nickel(II) iodide; lithium hexamethyldisilazane / isopropyl alcohol

3: hydrogenchloride / 1,4-dioxane; dichloromethane

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

With nickel(II) iodide; hydrogenchloride; carbon tetrabromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; isopropyl alcohol; acetonitrile; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.08.048

Reference yield:

: 1225276-07-2
tert-butyl 2-bromo-7-azaspiro[3.5]nonane-7-carboxylate

: 1225275-49-9
N-(3,4-dimethylisoxazol-5-yl)-2-(3-methoxyphenyl)-7-azaspiro[3.5]nonane-7-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: nickel(II) iodide; lithium hexamethyldisilazane / isopropyl alcohol

2: hydrogenchloride / 1,4-dioxane; dichloromethane

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

With nickel(II) iodide; hydrogenchloride; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In 1,4-dioxane; dichloromethane; isopropyl alcohol; acetonitrile; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.08.048