240401-28-9

Basic information

• Product Name: 7-Boc-2-hydroxy-7-azaspir...
• Synonyms: 7-Boc-2-hydroxy-7-azaspir...;7-Boc-2-hydroxy-7-azaspiro[3.5]nonane;7-Tert-butoxycarbonyl-7-azaspiro[3.5]nonan-2-ol;2-Hydroxy-7-aza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester;tert-Butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate - B7194
• CAS NO: 240401-28-9
• Molecular Formula: C₁₃H₂₃NO₃
• Molecular Weight: 241.32662
• Mol File: 240401-28-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 350.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.12±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.99±0.20(Predicted)
• CAS DataBase Reference: 7-Boc-2-hydroxy-7-azaspir...(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Boc-2-hydroxy-7-azaspir...(240401-28-9)
• EPA Substance Registry System: 7-Boc-2-hydroxy-7-azaspir...(240401-28-9)

Safety Data

• Hazardous Substances Data: 240401-28-9(Hazardous Substances Data)

Usage

General Description

7-Boc-2-hydroxy-7-azaspiro[2.4]heptane-2-carboxylic acid is a chemical compound that belongs to the class of azaspiro compounds. It is a derivative of the spiro[2.4]heptane ring system and contains a Boc (tert-butyloxycarbonyl) protecting group at the 7-position and a hydroxy group at the 2-position. 7-Boc-2-hydroxy-7-azaspir... has potential applications in medicinal chemistry, particularly in the development of pharmaceuticals and biologically active molecules. The Boc protecting group can be removed under mild conditions to reveal the free amine, making it a useful building block in organic synthesis. Its unique structure and functional groups make it a valuable intermediate in the synthesis of diverse compounds for various applications.

Upstream product

• 203661-69-2 tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate 
• 159635-49-1 tert-butyl 4-methylidenepiperidine-1-carboxylate 
• 396653-31-9 tert-butyl 1,1-dichloro-2-oxo-7-azaspiro[3.5]nonane-7-carboxylate 

Downstream Products

• 1421270-68-9 C₂₄H₂₆Cl₂FN₅O 
• 1421270-73-6 (R)-tert-butyl 2-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-7-azaspiro[3.5]nonane-7-carboxylate 
• 203662-66-2 2-cyano-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester 
• 1239319-82-4 2-amino-7-aza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester 
• 1256241-04-9 3-ethoxycarbonyl-isoxazol-5-ylmethyl 2-(4-chlorophenoxy)-7-aza-spiro[3.5]nonane-7-carboxylate 
• 1256241-03-8 2-(4-chlorophenoxy)-7-aza-spiro[3.5]-nonane 
• 1256240-60-4 3-carbamoyl-isoxazol-5-ylmethyl 2-(4-chlorophenoxy)-7-aza-spiro[3.5]nonane-7-carboxylate 
• 1256240-59-1 3-methylcarbamoyl-isoxazol-5-ylmethyl 2-(4-chlorophenoxy)-7-aza-spiro[3.5]nonane-7-carboxylate 
• 1346515-32-9 C₂₁H₂₄F₃N₃O₂ 
• 1346515-31-8 C₂₁H₂₄F₃N₃O₃ 
• 1225275-48-8 N-(3,4-dimethylisoxazol-5-yl)-2-[3-(trifluoromethoxy)phenyl]-7-azaspiro[3.5]nonane-7-carboxamide 
• 1346515-30-7 C₂₁H₂₄F₃N₃O₃ 

Relevant articles and documents

Stereoselective Diboration of Spirocyclobutenes: A Platform for the Synthesis of Spirocycles with Orthogonal Exit Vectors

The diastereo- and enantioselective diboration of spirocyclobutenes provides a platform for the rapid preparation of a wide variety of chiral spirocyclic building blocks. The chemoselective functionalization of the carbon-boron bond in the products, including a stereospecific sp3-sp2 Suzuki–Miyaura cross-coupling reaction, provides a powerful tool to control the directionality and the nature of the exit vectors in the spirocyclic framework.

ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4

Disclosed herein are substituted 7-azaspiro[3.5]nonane compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical co

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