N-(3,5-dimethoxyphenyl)-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-3 -(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinamine

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Chemical Name:N-(3,5-dimethoxyphenyl)-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-3 -(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinamine
CAS No.:1346245-08-6
Molecular Formula:C₂₈H₃₇N₅O₃Si
Molecular Weight:519.719
Hs Code.:

Synonyms:N-(3,5-dimethoxyphenyl)-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-3 -(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinamine

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Chemical Property of N-(3,5-dimethoxyphenyl)-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-3 -(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinamine

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Technology Process of N-(3,5-dimethoxyphenyl)-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-3 -(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinamine

There total 17 articles about N-(3,5-dimethoxyphenyl)-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-3 -(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.6%

: 1083325-87-4
7‐bromo‐2‐(1‐methyl‐1H‐pyrazol‐4‐yl)quinoxaline

: 1346245-09-7
N-(2-(((1,1-dimethylethyl)dimethylsilyl)oxy)ethyl)-3,5-dimethoxyaniline

: 1346245-08-6
N-(3,5-dimethoxyphenyl)-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-3 -(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinamine

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,2-dimethoxyethane; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 89891-65-6
7-bromo-2-chloroquinoxaline

: 1346245-08-6
N-(3,5-dimethoxyphenyl)-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-3 -(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,2-dimethoxyethane; water / 4 h / Reflux

2.1: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 90 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C / Inert atmosphere

3.2: 5 - 20 °C / Inert atmosphere

With sodium hydride; sodium carbonate; sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 82031-32-1
7-bromo-1H-quinoxalin-2-one

: 1346245-08-6
N-(3,5-dimethoxyphenyl)-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-3 -(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 2 h / 100 °C

1.2: Cooling with ice

2.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,2-dimethoxyethane; water / 4 h / Reflux

3.1: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 90 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C / Inert atmosphere

4.2: 5 - 20 °C / Inert atmosphere

With sodium hydride; sodium carbonate; sodium t-butanolate; trichlorophosphate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil;