7-Bromo-2-chloroquinoxaline

Base Information

• Chemical Name: 7-Bromo-2-chloroquinoxaline
• CAS No.: 89891-65-6
• Molecular Formula: C8H4 Br Cl N2
• Molecular Weight: 243.49
• Hs Code.: 2933990090
• European Community (EC) Number: 853-902-9
• DSSTox Substance ID: DTXSID00406760
• Wikidata: Q72453615
• Mol file: 89891-65-6.mol

Synonyms:7-bromo-2-chloroquinoxaline;89891-65-6;MFCD02955309;QUINOXALINE, 7-BROMO-2-CHLORO-;7-bromo-2-chloro-quinoxaline;2-chloro-7-bromo-quinoxaline;SCHEMBL361089;DTXSID00406760;AZUMKBQKUXTHCM-UHFFFAOYSA-N;7-bromanyl-2-chloranyl-quinoxaline;AKOS005620591;AB12778;CS-W019688;GS-4133;7-bromo-2-chloroquinoxaline, AldrichCPR;SY018860;AM20070397;FT-0648978;EN300-192333;A843369;AO-147/14849001;J-519115;Z1269110087

Chemical Property of 7-Bromo-2-chloroquinoxaline

Chemical Property:

• Boiling Point: 312.5±37.0 °C(Predicted)
• PKA: -2.50±0.30(Predicted)
• PSA: 25.78000
• Density: 1.762
• LogP: 3.04570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 241.92464
• Heavy Atom Count: 12
• Complexity: 167

Purity/Quality:

97% ^*data from raw suppliers

7-Bromo-2-chloroquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC=C(N=C2C=C1Br)Cl

Technology Process of 7-Bromo-2-chloroquinoxaline

There total 6 articles about 7-Bromo-2-chloroquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-hydroxy-7-bromoquinoxaline (82031-32-1) → 7-bromo-2-chloroquinoxaline (89891-65-6)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 2h; Inert atmosphere;

Reference yield: 96.0%

7-bromo-1H-quinoxalin-2-one (82031-32-1) → 7-bromo-2-chloroquinoxaline (89891-65-6)

Guidance literature:

With trichlorophosphate; for 2h; Heating / reflux;

Reference yield: 58.0%

glyoxylic acid ethyl ester (924-44-7) + 1,2-diamino-benzene (95-54-5) → 7-bromo-2-chloroquinoxaline (89891-65-6)

Guidance literature:

glyoxylic acid ethyl ester; 1,2-diamino-benzene; In ethanol; at 120 ℃; for 18h;

With bromine; In acetic acid; for 1h;

With trichlorophosphate; In diethyl ether; for 18h; Heating / reflux;

upstream raw materials:

7-bromo-1H-quinoxalin-2-one

glyoxylic acid ethyl ester

1,2-diamino-benzene

quinoxalin-2⁽¹⁾-one

Downstream raw materials:

7-bromoquinoxaline-2-amine

4-(7-bromoquinoxalin-2-yl)morpholine

N-{5-[3-(2-furanyl)-6-quinoxalinyl]-3-pyridinyl}benzenesulfonamide

7-bromo-2-{4-[2-(methyloxy)phenyl]-1-piperazinyl}quinoxaline