(2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histdine

Base Information

• Chemical Name: (2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histdine
• CAS No.: 133230-87-2
• Molecular Formula: C₂₃H₁₉F₅N₄O₅
• Molecular Weight: 526.42
• Mol file: 133230-87-2.mol

Synonyms:(2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histdine

Chemical Property of (2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histdine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histdine

There total 4 articles about (2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histdine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histidine methyl ester (133230-76-9) → (2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histdine (133230-87-2)

Guidance literature:

With sodium hydroxide; In ethanol;

DOI:10.1021/jo00012a019

Reference yield:

2,3,4,5,6-pentafluorobenzyl chloroformate (53526-74-2) → (2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histdine (133230-87-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent

2: 70 percent / dicyclohexylcarbodiimide

3: 65 percent / NaOH / aq. ethanol

With sodium hydroxide; dicyclohexyl-carbodiimide; In ethanol;

DOI:10.1021/jo00012a019

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → (2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histdine (133230-87-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent

2: 70 percent / dicyclohexylcarbodiimide

3: 65 percent / NaOH / aq. ethanol

With sodium hydroxide; dicyclohexyl-carbodiimide; In ethanol;

DOI:10.1021/jo00012a019

upstream raw materials:

(2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histidine methyl ester

2,3,4,5,6-pentafluorobenzyl chloroformate

L-phenylalanine

(2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-Phe-OH