(2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histidine methyl ester

Base Information

• Chemical Name: (2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histidine methyl ester
• CAS No.: 133230-76-9
• Molecular Formula: C₂₄H₂₁F₅N₄O₅
• Molecular Weight: 540.447
• Mol file: 133230-76-9.mol

Synonyms:(2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histidine methyl ester

Chemical Property of (2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histidine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histidine methyl ester

There total 3 articles about (2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histidine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-Phe-OH (133230-68-9) + L-histidine methyl ester dihydrochloride (7389-87-9) → (2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histidine methyl ester (133230-76-9)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1021/jo00012a019

Reference yield:

2,3,4,5,6-pentafluorobenzyl chloroformate (53526-74-2) → (2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histidine methyl ester (133230-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent

2: 70 percent / dicyclohexylcarbodiimide

With dicyclohexyl-carbodiimide;

DOI:10.1021/jo00012a019

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → (2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histidine methyl ester (133230-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent

2: 70 percent / dicyclohexylcarbodiimide

With dicyclohexyl-carbodiimide;

DOI:10.1021/jo00012a019

upstream raw materials:

(2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-Phe-OH

L-histidine methyl ester dihydrochloride

2,3,4,5,6-pentafluorobenzyl chloroformate

L-phenylalanine

Downstream raw materials:

(2,3,4,5,6-pentafluorobenzyloxycarbonyl)-L-phenylalanyl-L-histdine