(R)-ethyl 2-(9-chloro-7-((4-isopropoxy-3-(trifluoromethyl)benzyl)oxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Base Information

Chemical Name:(R)-ethyl 2-(9-chloro-7-((4-isopropoxy-3-(trifluoromethyl)benzyl)oxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate
CAS No.:1333379-92-2
Molecular Formula:C₂₆H₂₇ClF₃NO₄
Molecular Weight:509.953
Hs Code.:

Synonyms:(R)-ethyl 2-(9-chloro-7-((4-isopropoxy-3-(trifluoromethyl)benzyl)oxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

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Chemical Property of (R)-ethyl 2-(9-chloro-7-((4-isopropoxy-3-(trifluoromethyl)benzyl)oxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

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Technology Process of (R)-ethyl 2-(9-chloro-7-((4-isopropoxy-3-(trifluoromethyl)benzyl)oxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

There total 15 articles about (R)-ethyl 2-(9-chloro-7-((4-isopropoxy-3-(trifluoromethyl)benzyl)oxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1333379-91-1
(R)-ethyl 2-(7-((4-isopropoxy-3-(trifluoromethyl)benzyl)oxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

: 1333379-92-2
(R)-ethyl 2-(9-chloro-7-((4-isopropoxy-3-(trifluoromethyl)benzyl)oxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Guidance literature:: With N-chloro-succinimide; In dichloromethane; at -5 ℃; for 0.833333h;

Reference yield:

: 3418-69-7
7-(benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-one

: 1333379-92-2
(R)-ethyl 2-(9-chloro-7-((4-isopropoxy-3-(trifluoromethyl)benzyl)oxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 18.17 h / 20 - 29 °C / Inert atmosphere

2.1: tert-butyl alcohol; copper(II) acetate monohydrate / (R)-1-[(S_P)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine / tetrahydrofuran / 17 h / 5 - 10 °C / Inert atmosphere

3.1: hydrogenchloride / ethyl acetate; water

3.2: 3.5 h / 2585.81 Torr / Parr shaker

4.1: caesium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

5.1: N-chloro-succinimide / dichloromethane / 0.83 h / -5 °C

With hydrogenchloride; N-chloro-succinimide; potassium tert-butylate; copper(II) acetate monohydrate; caesium carbonate; tert-butyl alcohol; (R)-1-[(S_P)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1333379-86-4
potassium 7-(benzyloxy)-2-(ethoxycarbonyl)-3H-pyrrolo[1,2-a]indol-1-olate

: 1333379-92-2
(R)-ethyl 2-(9-chloro-7-((4-isopropoxy-3-(trifluoromethyl)benzyl)oxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; acetic acid / 40 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 18.17 h / 20 - 29 °C / Inert atmosphere

3.1: tert-butyl alcohol; copper(II) acetate monohydrate / (R)-1-[(S_P)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine / tetrahydrofuran / 17 h / 5 - 10 °C / Inert atmosphere

4.1: hydrogenchloride / ethyl acetate; water

4.2: 3.5 h / 2585.81 Torr / Parr shaker

5.1: caesium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

6.1: N-chloro-succinimide / dichloromethane / 0.83 h / -5 °C

With hydrogenchloride; N-chloro-succinimide; potassium tert-butylate; water; copper(II) acetate monohydrate; caesium carbonate; acetic acid; tert-butyl alcohol; (R)-1-[(S_P)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;