tert-butyl {[trans-4-({[(2-{3-[2-(dimethylamino)ethoxy]azetidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

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Chemical Name:tert-butyl {[trans-4-({[(2-{3-[2-(dimethylamino)ethoxy]azetidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate
CAS No.:1165799-53-0
Molecular Formula:C₃₀H₄₅N₅O₄
Molecular Weight:539.718
Hs Code.:

Synonyms:tert-butyl {[trans-4-({[(2-{3-[2-(dimethylamino)ethoxy]azetidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

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Chemical Property of tert-butyl {[trans-4-({[(2-{3-[2-(dimethylamino)ethoxy]azetidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

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Technology Process of tert-butyl {[trans-4-({[(2-{3-[2-(dimethylamino)ethoxy]azetidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

There total 4 articles about tert-butyl {[trans-4-({[(2-{3-[2-(dimethylamino)ethoxy]azetidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1165800-49-6
C₂₆H₃₆N₄O₄

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 1165799-53-0
tert-butyl {[trans-4-({[(2-{3-[2-(dimethylamino)ethoxy]azetidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

Guidance literature:: C₂₆H₃₆N₄O₄; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; Inert atmosphere;

(2-chloroethyl)dimethylamine hydrochloride; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.04.014

Reference yield:

: 1165797-46-5
tert-butyl {[trans-4-({[(2-chloroquinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

: 1165799-53-0
tert-butyl {[trans-4-({[(2-{3-[2-(dimethylamino)ethoxy]azetidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; sodium hydrogencarbonate / 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

2.2: 16 h / 50 °C / Inert atmosphere

With pyridine; sodium hydride; sodium hydrogencarbonate; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2011.04.014

Reference yield:

: 5467-57-2
2-chloroquinoline-4-carboxylic acid

: 1165799-53-0
tert-butyl {[trans-4-({[(2-{3-[2-(dimethylamino)ethoxy]azetidin-1-yl}quinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 2-methyltetrahydrofuran; water / 96 h / 20 °C / Inert atmosphere

2.1: pyridine; sodium hydrogencarbonate / 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

3.2: 16 h / 50 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 2-methyltetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2011.04.014